Results 21 to 30 of about 107,923 (299)

Combination of Antioxidant Enzyme Overexpression and N‐Acetylcysteine Treatment Enhances the Survival of Bone Marrow Mesenchymal Stromal Cells in Ischemic Limb in Mice With Type 2 Diabetes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Therapy with mesenchymal stem cells remains a promising but challenging approach to critical limb ischemia in diabetes because of the dismal cell survival.
Qiang Zhu, Hong Hao, Huifang Xu, Yosef Fichman, Yuqi Cui, Chunlin Yang, Meifang Wang, Ron Mittler, Michael A. Hill, Peter J. Cowan, Guangsen Zhang, Xiaoming He, Shenghua Zhou, Zhenguo Liu   +13 more
doaj   +1 more source

Elastin-like hydrogel stimulates angiogenesis in a severe model of critical limb ischemia (CLI): An insight into the glyco-host response.

Biomaterials, 2021
Critical limb ischemia (CLI) is characterized by the impairment of microcirculation, necrosis and inflammation of the muscular tissue. Although the role of glycans in mediating inflammation has been reported, changes in the glycosylation following muscle
Grazia Marsico, C. Jin, S. Abbah, E. Brauchle, Dilip Thomas, A. L. Rebelo, D. Orbanić, S. Chantepie, P. Contessotto, D. Papy-Garcia, C. Rodriguez-Cabello, M. Kilcoyne, K. Schenke-Layland, N. Karlsson, Karl J. A. McCullagh, A. Pandit   +15 more
semanticscholar   +1 more source

PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia

JACC: Basic to Translational Science, 2023
Summary: Hypoxia-induced endothelial cell death and impaired angiogenesis are the main pathophysiological features of critical limb ischemia. Mechanistically, proprotein convertase subtilisin/kexin type 9 (PCSK9) promoted Smac translocation from ...
Meixin Zhang, MM, Yixi Chen, PhD, Yumin Qiu, PhD, Jiapan Sun, PhD, Jiang He, PhD, Zhefu Liu, MM, Jian Shi, PhD, Wenbin Wei, MD, Guifu Wu, PhD, Jianwen Liang, PhD   +9 more
doaj   +1 more source

Critical Limb Ischemia: Current Trends and Future Directions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Martin Teraa, Michael S. Conte, Frans L. Moll, Marianne C. Verhaar   +3 more
doaj   +3 more sources

Chronic Critical Limb Ischemia [PDF]

Deutsches Ärzteblatt international, 2012
Some 40 000 lower limb amputations are performed in Germany each year, 70% of them in diabetics. About 80% of all major amputations may be preventable with the use of new interventional and vascular surgical procedures, particularly on the arteries of the leg and foot. We present the current state of the art in revascularization techniques and evaluate
Dohmen, Arndt, Eder, Stephan, Euringer, Wulf, Zeller, Thomas, Beyersdorf, Friedhelm   +4 more
openaire   +3 more sources

Endothelial Progenitor Cells May Be Related to Major Amputation after Angioplasty in Patients with Critical Limb Ischemia

Cells, 2023
Background: Critical limb ischemia represents an advanced stage of peripheral arterial disease. Angioplasty improves blood flow to the limb; however, some patients progress irreversibly to lower limb amputation.
Daniel Santillán-Cortez, Eduardo Vera-Gómez, Alejandro Hernández-Patricio, Atzín Suá Ruíz-Hernández, Juan Ariel Gutiérrez-Buendía, Karen De la Vega-Moreno, Yasser Alberto Rizo-García, Oscar Antonio Loman-Zuñiga, Ignacio Escotto-Sánchez, Juan Miguel Rodríguez-Trejo, Mario Antonio Téllez-González, Christian Gabriel Toledo-Lozano, Tania Ortega-Rosas, Silvia García, Paul Mondragón-Terán, Juan Antonio Suárez-Cuenca   +15 more
doaj   +1 more source

Cell Therapy for Critical Limb Ischemia: Advantages, Limitations, and New Perspectives for Treatment of Patients with Critical Diabetic Vasculopathy

Current Diabetes Reports, 2021
Purpose of Review To provide a highlight of the current state of cell therapy for the treatment of critical limb ischemia in patients with diabetes. Recent Findings The global incidence of diabetes is constantly growing with consequent challenges for ...
Y. Gu, A. Rampin, V. Alvino, G. Spinetti, P. Madeddu   +4 more
semanticscholar   +1 more source

Limb salvage following below-the-ankle angioplasty in critical limb ischemia

Indian Journal of Vascular and Endovascular Surgery, 2020
Aim: The aim was to report limb salvage following below-the-ankle (BTA) angioplasty as an adjunct to proximal angioplasty in patients with critical limb ischemia (CLI).
B Nishan, K Siva Krishna, V Vishal Hudgi, V P Ahsan, Vivek Anand   +4 more
doaj   +1 more source

Endovascular treatment of critical lower limb ischemia caused by giant cell arteritis

Journal of Vascular Surgery Cases and Innovative Techniques, 2019
Giant cell arteritis (GCA) is a well-known cause of cranial vasculitis often presenting with headache and jaw claudication. Here we report the case of a woman suffering GCA who presented with critical lower limb ischemia.
Rohan H.P. McLachlan, MD, BMS, Andrew F. Lennox, MBBS, MSc, FRACS, Ramon L. Varcoe, MBBS, MS, FRACS, Shannon D. Thomas, BSc Med Hons, MBBS, FRACS   +3 more
doaj   +1 more source

Sympathectomy and Neuromodulation in the Treatment of Critical Lower Limb Ischemia

Неотложная медицинская помощь, 2022
INTRODUCTION Critical lower limb ischemia is a widespread disease that occurs due to atherosclerotic lesions of the arteries with progressive narrowing of their lumen.
A. V. Yarikov, V. A. Leonov, M. V. Shpagin, O. A. Perlmutter, A. P. Fraerman, А. S. Mukhin, A. E. Kletskin, V. G. Lyutikov, D. G. Kuzminykh   +8 more
doaj   +1 more source