Results 31 to 40 of about 39,076 (258)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Assessment of limb ischemia among Patients with Traumatic injury [PDF]

Egyptian Journal of Health Care
Background: patients with traumatic injuries have several concurrent risk factors for limb ischemia which is a critical vascular emergency As a result, they demand assessment, prevention, early detection, and management, which may shorten hospital stays ...
Hanaa Tharwat Mohamed, Amany Safwat, Amira Hedaya   +2 more
doaj   +1 more source

NEXT AND LONG-TERM RESULTS OF X-RAY ENDOVASCULAR INTERVENTIONS IN TREATMENT OF CHRONIC CRITICAL ATHERODIABETIC ISCHEMIA OF LOWER EXTREMITIES

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. The treatment of chronic critical ischemia of the lower extremities with their combined atherodiabetic lesion is one of the far from the resolved problems of modern surgery. Aim of the study.
Ioskevich N. N., Vasilchuk L. F., Vankovich P. E., Antonenko S. P., Cherniy V. A., Obuhovich A. R.   +5 more
doaj   +1 more source

Application of autologous hemopoietic stem cells in inoperable patients with chronic critical lower limb ischemia

Вестник хирургии имени И.И. Грекова, 2022
The OBJECTIVE was to study the efficiency of transplantation of autologous hematopoietic stem cells in patients with chronic critical lower limb ischemia and compare the results of treatment depending on the number of their transplantations.METHODS AND ...
I. P. Mikhaylov, N. V. Borovkova, N. E. Kudrjashova, B. V. Kozlovskij, I. N. Ponomarjov, O. V. Leshсhinskaja   +5 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Gangrene, revascularization, and limb function improved with E-selectin/adeno-associated virus gene therapy

JVS - Vascular Science, 2021
Objective: Novel therapeutic angiogenic concepts for critical limb ischemia are still needed for limb salvage. E-selectin, a cell-adhesion molecule, is vital for recruitment of the stem/progenitor cells necessary for neovascularization in ischemic ...
Hallie J. Quiroz, MD, Punam P. Parikh, MD, Roberta M. Lassance-Soares, PhD, Manuela M. Regueiro, PhD, Yan Li, PhD, Hongwei Shao, PhD, Roberto Vazquez-Padron, PhD, Justin Percival, PhD, Zhao-Jun Liu, MD, PhD, Omaida C. Velazquez, MD   +9 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Noncoding RNAs in Critical Limb Ischemia [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
Peripheral artery disease, caused by chronic arterial occlusion of the lower extremities, affects over 200 million people worldwide. Peripheral artery disease can progress into critical limb ischemia (CLI), its more severe manifestation, which is associated with higher risk of limb amputation and cardiovascular death. Aiming to improve tissue perfusion,
Daniel, Pérez-Cremades, Henry S, Cheng, Mark W, Feinberg   +2 more
openaire   +2 more sources

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source