Results 51 to 60 of about 5,041,885 (292)

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Assessment of limb ischemia among Patients with Traumatic injury [PDF]

Egyptian Journal of Health Care
Background: patients with traumatic injuries have several concurrent risk factors for limb ischemia which is a critical vascular emergency As a result, they demand assessment, prevention, early detection, and management, which may shorten hospital stays ...
Hanaa Tharwat Mohamed, Amany Safwat, Amira Hedaya   +2 more
doaj   +1 more source

Frailty for Critical Limb Ischemia [PDF]

Circulation: Cardiovascular Interventions, 2018
See Article by Takeji et al Critical limb ischemia (CLI), despite advancements in revascularization technology and technical approaches, continues to be associated with significant morbidity and mortality.1–3 Although most operators consider endovascular approach as the first-line therapy for CLI,2–5 controversy remains as to which approach (medical,
Mehdi H, Shishehbor, Jun, Li
openaire   +2 more sources

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

NEXT AND LONG-TERM RESULTS OF X-RAY ENDOVASCULAR INTERVENTIONS IN TREATMENT OF CHRONIC CRITICAL ATHERODIABETIC ISCHEMIA OF LOWER EXTREMITIES

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. The treatment of chronic critical ischemia of the lower extremities with their combined atherodiabetic lesion is one of the far from the resolved problems of modern surgery. Aim of the study.
Ioskevich N. N., Vasilchuk L. F., Vankovich P. E., Antonenko S. P., Cherniy V. A., Obuhovich A. R.   +5 more
doaj   +1 more source

Application of autologous hemopoietic stem cells in inoperable patients with chronic critical lower limb ischemia

Вестник хирургии имени И.И. Грекова, 2022
The OBJECTIVE was to study the efficiency of transplantation of autologous hematopoietic stem cells in patients with chronic critical lower limb ischemia and compare the results of treatment depending on the number of their transplantations.METHODS AND ...
I. P. Mikhaylov, N. V. Borovkova, N. E. Kudrjashova, B. V. Kozlovskij, I. N. Ponomarjov, O. V. Leshсhinskaja   +5 more
doaj   +1 more source

Randomized controlled trial of dual antiplatelet therapy in patients undergoing surgery for critical limb ischemia [PDF]

, 2010
Patients with critical limb ischemia have a perioperative cardiovascular morbidity comparable to patients with acute coronary syndromes. We hypothesized that perioperative dual antiplatelet therapy would improve biomarkers of atherothrombosis without ...
Dawson, A Raymond W, Fox, Keith A A, O. James Garden, Newby, David E, John A. Murie, Keith A. A. Fox, David E. Newby, Anne Burdess, Garden, O James, Burdess, Anne, A. Raymond W. Dawson, Murie, John A, Nimmo, Alastair F, Alastair F. Nimmo   +13 more
core   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Chronic critical limb ischemia: European experiences

, 2009
Chronic critical limb ischemia still poses a substantial threat to both limb and life of the affected patients since these patients suffer typically also from associated cardiac and cerebrovascular disease and other severe comorbidities.
Silvestro, A, Do, DD, Diehm, N, Schmidli, J, Diehm, C, Baumgartner, I, Dick, F   +6 more
core   +1 more source

Ischemic polyneuropathy in patients with critical lower limb ischemia

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Background. Polyneuropathy is one of the complications of critical limb ischemia. In 30% of patients with critical limb ischemia, polyneuropathy occurs solely as a result of chronic tissue ischemia and is termed "ischemic polyneuropathy." In the ...
G. R. Ramazanov, E. V. Shevchenko, N. R. Ivanov, E. A. Kovaleva, L. S. Kokov, I. P. Mikhailov, B. V. Kozlovskiy, E. G. Seliverstova   +7 more
doaj   +1 more source