Results 51 to 60 of about 107,923 (299)

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Role of duplex-guided infragenicular angioplasty in saving limbs

Journal of the Arab Society for Medical Research, 2022
Background/aim Critical limb ischemia (CLI) is known as ischemic rest pain at rest or tissue loss with peripheral arterial disease. Endovascular intervention has many advantages than surgical bypasses and it is used frequently with fragile patients, at ...
Sameh E Elimam, Hala M Shereif
doaj   +1 more source

Endovascular Management of Critical Limb Ischemia [PDF]

Journal of Vascular Surgery, 2010
Endovascular management of critical limb ischemia has advanced significantly in the recent past, especially the ability to treat tibial artery lesions with reasonable results. The indications, results, and technical aspects or endovascular management of CLI is reviewed herein.
Blevins, W.A., Schneider, P.A.
openaire   +3 more sources

Autologous bone marrow mesenchymal stromal cell therapy for "no-option" critical limb ischemia is limited by karyotype abnormalities.

Cytotherapy, 2020
BACKGROUND Critical limb ischemia (CLI) is the most severe manifestation of peripheral vascular disease. Revascularization is the preferred therapy, but it is not achievable in 25%-40% of patients due to diffuse anatomic distribution of the disease or ...
S. Mohamed, Linda Howard, Veronica McInerney, A. Hayat, J. Krawczyk, S. Naughton, A. Finnerty, M. Holohan, A. Duffy, T. Moloney, E. Kavanagh, P. Burke, A. Liew, M. Tubassam, S. Walsh, T. O’Brien   +15 more
semanticscholar   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Post-treatment neutrophil-lymphocyte ratio independently predicts amputation in critical limb ischemia without operation

Clinics, 2015
OBJECTIVES: Limited information is available concerning the post-treatment neutrophil-lymphocyte ratio in critical limb ischemia patients who receive conservative therapy.
Han Luo, Ding Yuan, Hongliu Yang, Ma Yukui, Bin Huang, Yi Yang, Fei Xiong, Guojun Zeng, Zhoupeng Wu, Xiyang Chen, Tiehao Wang, Hailong Luo, Jichun Zhao   +12 more
doaj   +1 more source

Limb Ischemia Complications of Veno-Arterial Extracorporeal Membrane Oxygenation

Frontiers in Medicine, 2022
BackgroundThis study aimed to summarize and analyse the risk factors, clinical features, as well as prevention and treatment of limb ischemia complications in patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO).MethodsWe ...
Sixiong Hu, Sixiong Hu, Sixiong Hu, Sixiong Hu, Andong Lu, Andong Lu, Andong Lu, Andong Lu, Chenliang Pan, Chenliang Pan, Chenliang Pan, Chenliang Pan, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Yong ling Wa, Wenjing Qu, Ming Bai, Ming Bai, Ming Bai, Ming Bai   +21 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Outcomes of Peripheral Vascular Interventions in Select Patients With Lower Extremity Acute Limb Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundContemporary data on patients presenting with acute limb ischemia (ALI), who are selected for treatment with endovascular peripheral vascular interventions (PVI), are limited.
Elica Inagaki, Alik Farber, Jeffrey A. Kalish, Mohammad H. Eslami, Jeffrey J. Siracuse, Robert T. Eberhardt, Denis V. Rybin, Gheorghe Doros, Naomi M. Hamburg   +8 more
doaj   +1 more source

Long term efficacy and safety of rivaroxaban plus cilostazol in the treatment of critical ischemia of the lower limbs in a frail, elderly patient with non valvular atrial fibrillation

Journal of Pharmaceutical Health Care and Sciences, 2020
Background Many patients with critical lower limb ischemia are not eligible for revascularization procedures. Still, given the emerging role of both platelet and coagulation activation in the formation of arterial thrombi, they may benefit from the novel
Antonio Trani, Pietro Benedetto, Ferdinando Di Leo, Angela Baiano, Andrea Esposito, Danilo Menna, Arianna Allegretti, Pierluigi Antonino Cappiello, Domenico Dell’Edera   +8 more
doaj   +1 more source