Results 61 to 70 of about 5,041,885 (292)

Gangrene, revascularization, and limb function improved with E-selectin/adeno-associated virus gene therapy

JVS - Vascular Science, 2021
Objective: Novel therapeutic angiogenic concepts for critical limb ischemia are still needed for limb salvage. E-selectin, a cell-adhesion molecule, is vital for recruitment of the stem/progenitor cells necessary for neovascularization in ischemic ...
Hallie J. Quiroz, MD, Punam P. Parikh, MD, Roberta M. Lassance-Soares, PhD, Manuela M. Regueiro, PhD, Yan Li, PhD, Hongwei Shao, PhD, Roberto Vazquez-Padron, PhD, Justin Percival, PhD, Zhao-Jun Liu, MD, PhD, Omaida C. Velazquez, MD   +9 more
doaj   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Treatment of critical lower limb ischemia using a hybrid technique [PDF]

, 2014
Critical ischemia of a lower limb is a condition that threatens its viability and must be treated promptly to avoid major amputation. Revascularization is the most effective treatment method and is performed using surgical or endovascular techniques. For
Pedro Victor Alcântara da Costa, Moreira,Ricardo Wagner da Costa, Costa,Pedro Victor Alcântara da, Carrilho,David Domingos Rosado, David Domingos Rosado Carrilho, Ricardo Wagner da Costa Moreira   +5 more
core   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Demographic and Comorbidity Pattern of Patients with Critical Limb Ischemia

, 2017
Aim: The present study aimed at identifying the pattern of patients with critical limb ischemia (CLI) compared with those with peripheral arterial occlusive disease (PAOD)
Ciocan Andra, Stancu Bogdan, Bolboacă Sorana D., Ciocan Răzvan A., Rădulescu Şerban, Gherman Claudia D.   +5 more
core   +1 more source

A novel laser-doppler flowmetry assisted murine model of acute hindlimb ischemia-reperfusion for free flap research [PDF]

, 2013
Suitable and reproducible experimental models of translational research in reconstructive surgery that allow in-vivo investigation of diverse molecular and cellular mechanisms are still limited.
Isabella Kanzler, Matthias Knobe, Christoph Jan Wruck, Frank Hölzle, Brandacher, Gerald, Nancy Tuchscheerer, David Mitchell, Athanassios Fragoulis, Hölzle, Frank, Kanatas, Anastasios, Mitchell, David, Wruck, Christoph Jan, Othman Al-Sawaf, René Tolba, Knobe, Matthias, Tohidnezhad, Mersedeh, Elisa Anamaria Liehn, Liehn, Elisa Anamaria, Sönmez, Tolga Taha, Anastasios Kanatas, Thomas Pufe, Pufe, Thomas, Al-Sawaf, Othman, Kanzler, Isabella, Tolga Taha Sönmez, Tolba, René H., Fragoulis, Athanassios, Mitchell, David A., Tuchscheerer, Nancy, Gerald Brandacher, Mersedeh Tohidnezhad, Tohidnezhad Mersedeh, Knobe Matthias, Fragoulis Athanassios, Pufe Thomas, Hölzle Frank, Tuchscheerer Nancy, Wruck Christoph Jan, Tolba René, Al-Sawaf Othman, Liehn Elisa Anamaria, Brandacher Gerald, Kanatas Anastasios, Sönmez Tolga Taha, Kanzler Isabella, Mitchell David   +45 more
core   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Post-treatment neutrophil-lymphocyte ratio independently predicts amputation in critical limb ischemia without operation

Clinics, 2015
OBJECTIVES: Limited information is available concerning the post-treatment neutrophil-lymphocyte ratio in critical limb ischemia patients who receive conservative therapy.
Han Luo, Ding Yuan, Hongliu Yang, Ma Yukui, Bin Huang, Yi Yang, Fei Xiong, Guojun Zeng, Zhoupeng Wu, Xiyang Chen, Tiehao Wang, Hailong Luo, Jichun Zhao   +12 more
doaj   +1 more source