Results 71 to 80 of about 5,041,885 (292)

Multivariate analysis of factors affecting overall amputation in patients with critical limb ischemia.

, 2016
Multivariate analysis of factors affecting overall amputation in patients with critical limb ischemia.
Jingqiang Zhu (2579947), Ding Yuan (142530), Jichun Zhao (120536), Bin Huang (331329), Han Luo (302386), Hongliu Yang (772489)   +5 more
core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Outcomes of Peripheral Vascular Interventions in Select Patients With Lower Extremity Acute Limb Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundContemporary data on patients presenting with acute limb ischemia (ALI), who are selected for treatment with endovascular peripheral vascular interventions (PVI), are limited.
Elica Inagaki, Alik Farber, Jeffrey A. Kalish, Mohammad H. Eslami, Jeffrey J. Siracuse, Robert T. Eberhardt, Denis V. Rybin, Gheorghe Doros, Naomi M. Hamburg   +8 more
doaj   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Long term efficacy and safety of rivaroxaban plus cilostazol in the treatment of critical ischemia of the lower limbs in a frail, elderly patient with non valvular atrial fibrillation

Journal of Pharmaceutical Health Care and Sciences, 2020
Background Many patients with critical lower limb ischemia are not eligible for revascularization procedures. Still, given the emerging role of both platelet and coagulation activation in the formation of arterial thrombi, they may benefit from the novel
Antonio Trani, Pietro Benedetto, Ferdinando Di Leo, Angela Baiano, Andrea Esposito, Danilo Menna, Arianna Allegretti, Pierluigi Antonino Cappiello, Domenico Dell’Edera   +8 more
doaj   +1 more source

Long term outcomes of diabetic haemodialysis patients with critical limb ischemia and foot ulcer

, 2016
To evaluate the outcomes of diabetic dialysis patients with critical limb ischemia and foot ...
Giurato, L, Gandini, R, Stefanini, M, Uccioli, L, GANDINI, ROBERTO, PAMPANA, ENRICO, Pampana, E, UCCIOLI, LUIGI, GIURATO, LAURA, MELONI, MARCO, STEFANINI, MATTEO, Meloni, M, Izzo, V   +12 more
core   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

A prognostic model for amputation in critical lower limb ischemia [PDF]

, 2009
In a (negative) multicenter randomized trial on management for inoperable critical lower limb ischemia, comparing spinal cord stimulation and best medical treatment, a number of pre-defined factors were analyzed for prognostic value.
Wittens, CHA, van Urk, H, Steyerberg, Ewout, Klomp, HM (Houke), Habbema, Dik   +4 more
core   +3 more sources

Endovascular Treatment of Acute Tibioperoneal Trunk Thrombosis. A Clinical Case Report

Креативная хирургия и онкология, 2019
Introduction. Acute limb ischemia is a severe disorder caused by a sharp drop in the arterial perfusion of the limb. It carries a threat to the limb’s function and viability.
D. S. Chigidinova, B. A. Rudenko, A. S. Shanoyan, V. P. Mazaev, F. B. Shukurov   +4 more
doaj   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source