Results 121 to 130 of about 6,661,624 (342)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Determination of the Critical State Line in Partially Frozen Sand

open access: yesGeotechnics
A new method for measuring internal pore water pressure (PWP) is introduced to determine the critical state line (CSL) in partially frozen sand, investigating the influence of temperature and strain rate on the critical state parameters.
Yawu Liang, Nicholas Beier, Dave C. Sego
doaj   +1 more source

Development of a Preventive Maintenance Strategy for an Automatic Production Line Based on Group Maintenance Method

open access: yesApplied Sciences, 2018
The high maintenance costs and low reliability of automatic production line are attributed to the complexity of maintenance management. In the present study, a preventive maintenance strategy for the automatic production line was developed based on the ...
Guofa Li   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

A Critical Investigation Into Extra-High Voltage Transmission Line: Bangladesh Perspective

open access: yesInternational Transactions on Electrical Energy Systems
Bangladesh intends to build a 5 GW transmission super-highway from Moheshkhali to Madunaghat to Bhulta to evacuate a bulk amount of power. This study presents the particle swarm optimization (PSO) method for estimating line parameters.
Deepak Kumar Chowdhury   +3 more
doaj   +1 more source

Mellin transforms with only critical zeros: generalized Hermite functions [PDF]

open access: yes, 2013
We consider the Mellin transforms of certain generalized Hermite functions based upon certain generalized Hermite polynomials, characterized by a parameter $\mu>-1/2$.
Coffey, Mark W.
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

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