The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Physiological parameters for thermal stress in dairy cattle
The objective of this study was to investigate changes in physiological parameters of dairy cows and understand which physiological parameters show greater reliability for verification of heat stress.
Vanessa Calderaro Dalcin +7 more
doaj +1 more source
Spin Glasses in a Field Show a Phase Transition Varying the Distance among Real Replicas (And How to Exploit It to Find the Critical Line in a Field). [PDF]
Dilucca M +4 more
europepmc +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Asymptotic formulas for harmonic series in terms of a non-trivial zero on the critical line
Artur Kawalec
openalex +1 more source
The Tomonaga-Luttinger Liquid with Quantum Impurity Revisited: Critical\n Line and Phase Diagram [PDF]
Taejin Lee
openalex +1 more source
Randomized Clinical Trials and Real World Prospective Observational Studies on Bevacizumab, PARP Inhibitors, and Immune Checkpoint Inhibitors in the First-Line Treatment of Advanced Ovarian Carcinoma: A Critical Review [PDF]
Angiolo Gadducci, Stefania Cosio
openalex +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source

