Results 131 to 140 of about 10,947,423 (301)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Riemann Zeta Function Near the Critical Line

open access: yes, 2014
See the values of the Riemann zeta function near the critical line in the complex plane. The height of the surface gives the absolute value; the color gives the phaseComponente Curricular::Educação Superior::Ciências Exatas e da Terra ...
Wolfram, Stephen, Trott, Michael
core  

Peer-learning and reflective thinking in an On-line community of learners [PDF]

open access: yes, 2001
There is a growth in the use of Computer Mediated Communications (CMC) in teacher education and professional development, together with a strong interest in creating reflective discourse communities among teachers. With the use of CMC, geographically and
Hendriks, V., Maor, D.
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

CESCA Newsletter

open access: yes, 2010
The Center for Embedded Systems for Critical Applications (CESCA) held its annual workshop titled “CESCA Day” at the Owens Banquet Hall in Blacksburg, Va., on May 6, 2010! Events included keynote, tutorials, poster sessions, and a student panel.
Virginia Tech. Center for Embedded Systems for Critical Applications
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Other title: Dealer on-line registration system

open access: yes, 1999
Rev. 10/99.; Cover title.; "Dealer On-Line Procedure Manual"--Introduction.; Accompanied by 1 sheet of automobile registration cards and 1 application for duplicate certificate of title, with cover ...
Connecticut. Department of Motor Vehicles. Dealers and Repairers Division
core   +2 more sources

The Critical Line in the Sky

open access: yes
For the complete framework see On the Nature of Nature https://doi.org/10.5281/zenodo ...
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

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