Results 81 to 90 of about 10,947,423 (301)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Regarding Physical and Chemical Transformations with the Involvement of Water Near –45 °C
Конденсированные среды и межфазные границы, 2019 Objective. A hypothesis about a new mechanism for accelerating chemical reactions involving supercooled water near -45 °С is presented. The hypothesis is based on the properties of the second critical point of water at a temperature of –53 °C and a ...
Georgy S. Bordonsky +1 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
On the critical lines of a graph [PDF]
Pacific Journal of Mathematics, 1967 Beineke, Lowell W. +2 more
openaire +2 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Field-induced vortex-like textures as a probe of the critical line in reentrant spin glasses. [PDF]
Sci Rep, 2021 Martin N +6 more
europepmc +1 more source
National Adult Critical Care Capacity Census and Activity Census 2016
, 2017 he annual national adult Critical Care Bed Capacity Census measures capacity as at 30th September 2016. The Census reports a capacity of 237 adult critical care (Level3 ICU and Level2 HDU) beds.
HSE Acute Hospitals Division Critical Care Programme
core
Research Handbook on Line Managers
, 2022 This timely Research Handbook brings together 24 chapters with a wide range of different theoretical perspectives, empirical research, and innovative thought provoking ideas relating to an area of organisation and management that has been neglected for ...
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core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source