Results 71 to 80 of about 10,947,423 (301)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Investigations of the Nature of Critical Line Very Close to a Double Critical Point
, 1991 The curvature of the line of critical points in a reentrant ternary mixture is determined by approaching the double critical point (DCP) extremely closely. The results establish the continuous and quadratic nature of this line.
Kumar, A +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Proposing a Rule for VSC-HVDC Optimal Placement to Improve Transient Stability of Power System [PDF]
International Journal of Research and Technology in Electrical IndustryTransient stability indicates the system's ability to dampen the rotor oscillations of synchronous generators after severe faults. The transient instability causes considerable damage to the generator and reduces the production capacity in the network ...
Ali Abrishami Moghaddam +2 more
doaj +1 more source
Tasmanian main line railway [cartographic material].
, 1880 Map showing the main railway line from Hobart to Launceston in red, the Mersey, Deloraine, Launceston and Western Railway in black and the projected line from Bridgewater in a broken red line.; Australian Encyclopedia, 6th ed., v. 7, p.
core
A note on withdrawal from a two-layer fluid through a line sink in a porous medium [PDF]
, 2008 The steady response of the free surface of a fluid in a porous medium is considered during extraction of the fluid through a line sink. A conformal-mapping approach is used to derive exact solutions to a family of problems in which the line sink is ...
Hocking, GC +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Evaluasi Penjadwalan Proyek Pengembangan Rumah Sakit Mitra Husada Pringsewu
Media Komunikasi Teknik Sipil, 2017 Project is a unique sequence of interrelated activities to achieve particular result and done in particular time period. Due to time and budget limitation, management undertaking of a project needs to be evaluated by using a special method in order to ...
Weka Indra Dharmawan +2 more
doaj +1 more source