Results 41 to 50 of about 133,969 (266)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Synergic process of molybdenum recovery and ceramic preparation for clean and efficient utilization of industrial leaching residues

Cleaner Engineering and Technology
Ammonia-leaching residues of roasted molybdenite concentrates are intractable wastes and are mostly stockpiled in factories. Common treatments suffer from low Mo recovery and secondary pollution. This study has developed a synergistic process involving a
Guihong Han, Yanghao Feng, Mengyu You, Hu Sun, Shengpeng Su, Bingbing Liu, Yanfang Huang   +6 more
doaj   +1 more source

Strange metal without magnetic criticality [PDF]

Science, 2015
A mysteriously misbehaving phase Two electrons in a vacuum repel each other because they carry like charges. But in a metal, with a bunch of other electrons, in some ways they behave as if they didn't interact. This phenomenon, known as the Fermi liquid (FL) behavior, comes with a typical quadratic dependence of the solid's ...
Tomita, Takahiro, Kuga, Kentaro, Uwatoko, Yoshiya, Coleman, Piers, Nakatsuji, Satoru   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A novel molybdenite depressant for efficient selective flotation separation of chalcopyrite and molybdenite

International Journal of Mining Science and Technology
A novel small molecule depressant (M-DEP) was used to separate chalcopyrite and molybdenite via flotation. The results showed that M-DEP had an excellent selective depression on molybdenite, while had little effect on the flotation of chalcopyrite.
Mengyao Qi, Weijun Peng, Wei Wang, Yijun Cao, Longyu Zhang, Yukun Huang   +5 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Accelerated Cu-Ti alloy design under data scarcity through fine-tuned transfer learning

Materials & Design
This study presents a novel machine learning framework using transfer learning (TL) to overcome data scarcity in designing high-performance Cu-Ti alloys with balanced high ultimate tensile strength (UTS) and electrical conductivity (EC).
Qiao Yin, Yuwei Liu, Hongliang Zhao, Jincheng Wang, Shuya Zhang, Yuheng Fan, Xianglei Dong, Yang Song, Chunwen Guo   +8 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source