Results 71 to 80 of about 457,166 (295)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
\u3cem\u3eSapere Aude\u3c/em\u3e: Critical Ontology and the Case of Child Development [PDF]
, 2004 This paper argues that Foucault’s proposed positive program of practical critique in his later work, which he calls ‘critical ontology,’ provides a response to his critics.
Wong, James
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
International Journal of Distributed Sensor Networks, 2014 The advancement of sensor technology has led to an explosive increase in sensors. It causes semantic heterogeneity problems, and much research has focused on sensor ontology building to solve the problems.
Sukhoon Lee +3 more
doaj +1 more source
A fuzzy ontology modeling for case base knowledge in diabetes mellitus domain
Engineering Science and Technology, an International Journal, 2017 Knowledge-Intensive Case-Based Reasoning Systems (KI-CBR) mainly depend on ontologies. Ontology can play the role of case-base knowledge. The combination of ontology and fuzzy logic reasoning is critical in the medical domain.
Shaker El-Sappagh, Mohammed Elmogy
doaj +1 more source
Comprendiendo y cuestionando la gobernanza global
Colombia Internacional, 2020 Objective/context: The article argues that although Global Governance (GG) is a widely analyzed phenomenon and a practice that is currently widespread, it is based on ontological assumptions that have not been sufficiently questioned.
Amaya Querejazu
doaj +1 more source
Managing Cultural Diversity in the Multinational Corporate Workplace: Solution or Symptom? [PDF]
, 2009 The aim of this paper is to show the critical relevance of post-structuralist political theory to cross-cultural management studies. By emphasizing the key role that questions of identity, difference, and struggle play in the multinational corporate ...
Angouri, J, Glynos, J
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Non-Coding RNA Ontology : a comprehensive resource for the unification of non-coding RNA biology [PDF]
, 2016 In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification.
Alan, Ruttenberg +9 more
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