Results 71 to 80 of about 5,619,131 (294)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Enabling Active Ontology Change Management within Semantic Web-based Applications. Mini-thesis: PhD upgrade report

, 2006
Enabling traceable ontology changes is becoming a critical issue for ontology-based applications. Updating an ontology that is in use may result in inconsistencies between the ontology and the knowledge base, dependent ontologies and applications ...
Liang, Yaozhong, Alani, Harith, Shadbolt, Nigel   +2 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Critical Ontology: An Introductory Essay

, 2002
This monograph contains the author’s initial reflections on "critical ontology." Conceived primarily as a method of doing philosophy in general and ontology in particular, critical ontology approves of the Kantian critique of knowledge, without, however,
Kaipayil, Joseph
core   +1 more source

Canonical Sensor Ontology Builder Based on ISO/IEC 11179 for Sensor Network Environments: A Standardized Approach

International Journal of Distributed Sensor Networks, 2014
The advancement of sensor technology has led to an explosive increase in sensors. It causes semantic heterogeneity problems, and much research has focused on sensor ontology building to solve the problems.
Sukhoon Lee, Dongwon Jeong, Jangwon Gim, Doo-Kwon Baik   +3 more
doaj   +1 more source

Critical realism and the ‘ontological politics of drug policy’ [PDF]

International Journal of Drug Policy, 2020
This article explores the question of what we can consider to be real in drug policy. It examines two increasingly common aspects of drug policy analysis; radical constructionist critique and successionist data science. It shows how researchers using these assumptions have produced interesting findings, but also demonstrates their theoretical ...
openaire   +3 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

obophenotype/cell-ontology: v2022-08-16

, 2022
What's Changed Edited telocyte by @bvarner-ebi in https://github.com/obophenotype/cell-ontology/pull/1721 Fixed typos for pituitary and basophilic by @bvarner-ebi in https://github.com/obophenotype/cell-ontology/pull/1723 Added gogoeditdiff trigger by ...
Jim Balhoff, Nico Matentzoglu, Bonita Lam, arwa-ebi, Damien Goutte-Gattat, Shawn Tan, Ray Stefancsik, Benjamin M. Gyori, Charles Tapley Hoyt, Matthew Brush, Alexander Diehl, Arwa Ibrahim, Chris Mungall, uberon, Aleix Puig, Arlene, David Osumi-Sutherland, bvarner-ebi, Nicole Vasilevsky, Ismail Ugur Bayindir, PaulaDRoggli, Maria Keays, ybradford, Melissa Haendel, Tiago Lubiana, JArgasinska, Jane Lomax, Anita Caron, Zoë May Pendlington, Alan Ruttenberg, Martin Larralde, paolaroncaglia, JoshuaFortriede   +32 more
core   +1 more source