Results 81 to 90 of about 2,179,018 (268)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Indications of a ferromagnetic quantum critical point in [Formula: see text]. [PDF]

Sci Rep, 2023
Holmes-Hewett WF, Van Koughnet K, Miller JD, Trewick EXM, Ruck BJ, Trodahl HJ, Buckley RG.   +6 more
europepmc   +1 more source

Symmetry & Critical Points

Critical points of an invariant function may or may not be symmetric. We prove, however, that if a symmetric critical point exists, those adjacent to it are generically symmetry breaking. This mathematical mechanism is shown to carry important implications for our ability to efficiently minimize invariant nonconvex functions, in particular those ...
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Existence of solutions for a two-point boundary-value problem of a fourth-order Sturm-Liouville type

Electronic Journal of Differential Equations, 2012
In this work, we establish the existence of two intervals for a parameter $lambda$ for which a two-point boundary-value problem of fourth-order Sturm-Liouville type admits three weak solutions whose norms are uniformly bounded with respect to $lambda$.
Shapour Heidarkhani
doaj  

Temperature Dependence of Optical Properties of MoS₂ and WS₂ Heterostructures Assessed by Spectroscopic Ellipsometry

Nanomaterials
We report the complex dielectric function ε = ε1 + iε2 of MoS2/WS2 and WS2/MoS2 heterostructures and their constituent monolayers MoS2 and WS2 for an energy range from 1.5 to 6.0 eV and temperatures from 39 to 300 K.
Hoang Tung Nguyen, Van Long Le, Thi Mai Nguyen, Xuan Khuyen Bui, Thi Giang Nguyen, Nhat Linh Nguyen, Xuan Au Nguyen, Tae Jung Kim   +7 more
doaj   +1 more source

Critical point for membrane bilayer formation. [PDF]

Biochim Biophys Acta Biomembr, 2023
Gershfeld NL, Nossal R.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Analysis of Shell Egg Pasteurization Using Computational Fluid Dynamics

Applied Sciences
In the present work, the thermal pasteurization process of shell eggs was studied through Computational Fluid Dynamics. For large-size eggs (63–72 g), the required heating times at several different heating medium (water) temperatures, namely 54, 56, 58,
Pavlos-Antonios Sampanis, Stylianos M. Chatzidakis, George N. Stoforos, Nikolaos G. Stoforos   +3 more
doaj   +1 more source