Results 91 to 100 of about 2,430,844 (266)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Perfect intrinsic squeezing at the superradiant phase transition critical point. [PDF]
Sci Rep, 2023 Hayashida K +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma. [PDF]
Ann Transl Med, 2022 Winkler T.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Electronic Journal of Differential Equations, 2014 In this article, we study elliptic problems of Kirchhoff type in dimension $ N \geq 2$, whose nonlinear term has a critical exponential growth. Using variational tools, we establish the existence of at least two nontrivial and nonnegative solutions.
Sami Aouaoui
doaj
Motif based hierarchical random graphs: structural properties and critical points of an Ising model
Condensed Matter Physics, 2011 A class of random graphs is introduced and studied. The graphs are constructed in an algorithmic way from five motifs which were found in [Milo R., Shen Orr S., Itzkovitz S., Kashtan N., Chklovskii D., Alon U., Science, 2002, vol. 298, 824 – 827].
M. Kotorowicz
doaj +1 more source
Cell-autonomous diversification in bacteria arises from calcium dynamics self-organizing at a critical point. [PDF]
Sci Adv, 2023 Meyer CT, Kralj JM.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source