Results 111 to 120 of about 10,934,305 (297)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A unified treatment using critical point methods of the existence of multiple solutions for superlinear and sublinear neumann problems

, 2011
In this paper we present a framework which permits the unified treatment of the existence of multiple solutions for superlinear and sublinear Neumann problems. Using critical point theory, truncation techniques, the method of upper-lower solutions, Morse
Motreanu, D, O'Regan, Donal, Papageorgiou, NS, Papageorgiou, Nikolaos S., Motreanu, D., Donal O'Regan, Nikolaos S. Papageorgiou, D. Motreanu, O'Regan, D   +8 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Perfect intrinsic squeezing at the superradiant phase transition critical point. [PDF]

Sci Rep, 2023
Hayashida K, Makihara T, Marquez Peraca N, Fallas Padilla D, Pu H, Kono J, Bamba M.   +6 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Cell-autonomous diversification in bacteria arises from calcium dynamics self-organizing at a critical point. [PDF]

Sci Adv, 2023
Meyer CT, Kralj JM.
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Existence of multiple solutions to elliptic problems of Kirchhoff type with critical exponential growth

Electronic Journal of Differential Equations, 2014
In this article, we study elliptic problems of Kirchhoff type in dimension $ N \geq 2$, whose nonlinear term has a critical exponential growth. Using variational tools, we establish the existence of at least two nontrivial and nonnegative solutions.
Sami Aouaoui
doaj  

Motif based hierarchical random graphs: structural properties and critical points of an Ising model

Condensed Matter Physics, 2011
A class of random graphs is introduced and studied. The graphs are constructed in an algorithmic way from five motifs which were found in [Milo R., Shen Orr S., Itzkovitz S., Kashtan N., Chklovskii D., Alon U., Science, 2002, vol. 298, 824 – 827].
M. Kotorowicz
doaj   +1 more source

Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma. [PDF]

Ann Transl Med, 2022
Winkler T.
europepmc   +1 more source