Results 141 to 150 of about 3,581,339 (338)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Minimax principles for critical-point theory in applications to quasilinear boundary-value problems

Electronic Journal of Differential Equations, 2000
Using the variational method developed by the same author in [7], we establish the existence of solutions to the equation $-Delta_p u = f(x,u)$ with Dirichlet boundary conditions.
A. R. El Amrouss, M. Moussaoui
doaj  

Infinitely many positive solutions for p-Laplacian equations with singular and critical growth terms

Boundary Value Problems
In this paper, we study the existence of multiple solutions for the following nonlinear elliptic problem of p-Laplacian type involving a singularity and a critical Sobolev exponent { − Δ p u = u p ∗ − 1 + λ | u | γ − 1 u , in Ω , u = 0 , on ∂ Ω ...
Chen-Xi Wang, Hong-Min Suo
doaj   +1 more source

Quantum critical point in theQED3theory of underdoped high-temperature superconductors [PDF]

, 2003
Dominic J. Lee, Igor F. Herbut
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Existence of three solutions for higher order BVP with parameters via Morse theory

Electronic Journal of Differential Equations, 2016
We prove the existence of at least three solutions to a general Lidstone problem using the Morse Theory.
Mariusz Jurkiewicz, Bogdan Przeradzki
doaj  

Editorial Conclusion for the Special Issue “New Theory and Applications of Nonlinear Analysis, Fractional Calculus and Optimization”

Axioms
Nonlinear analysis has widespread and significant applications in many areas at the core of many branches of pure and applied mathematics and modern science, including nonlinear ordinary and partial differential equations, critical point theory ...
Wei-Shih Du
doaj   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Multiple solutions of nonlinear fractional elliptic equations via Morse theory

Electronic Journal of Differential Equations, 2017
This article concerns the existence and multiplicity of weak solutions of the nonlinear fractional elliptic problem. We extend some well known results of semilinear Laplacian equations to the nonlocal fractional setting. Using the variational methods
Wei Qi, Lin Zhao, Xingjie Yan
doaj  

Critical point theory in Hilbert space under regular boundary conditions

, 1971
E. H. Rothe
openalex   +1 more source