Results 121 to 130 of about 450,232 (306)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Variational Methods and Critical Point Theory 2013
Abstract and Applied Analysis, 2013 M. Victoria Otero-Espinar +3 more
doaj +1 more source
Infinite dimensional extensions of the Landesman-Lazer theorem
Electronic Journal of Differential Equations, 2021 Martin Schechter
doaj
A note on quasilinear elliptic eigenvalue problems
Electronic Journal of Differential Equations, 1999 We study an eigenvalue problem by a non-smooth critical point theory. Under general assumptions, we prove the existence of at least one solution as a minimum of a constrained energy functional. We apply some results on critical point theory with symmetry
Gianni Arioli
doaj
, 2014 Dr. Chao Wang and his Ph.D. student, Hassan Eldib, received the Best Paper Award at the International Conference on Formal Methods in Computer Aided Design (FMCAD) in November 2013 for a paper titled “An SMT based method for optimizing arithmetic ...
Virginia Tech. Center for Embedded Systems for Critical Applications
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Minimax principles for critical-point theory in applications to quasilinear boundary-value problems
Electronic Journal of Differential Equations, 2000 Using the variational method developed by the same author in [7], we establish the existence of solutions to the equation $-Delta_p u = f(x,u)$ with Dirichlet boundary conditions.
A. R. El Amrouss, M. Moussaoui
doaj
AxiomsNonlinear analysis has widespread and significant applications in many areas at the core of many branches of pure and applied mathematics and modern science, including nonlinear ordinary and partial differential equations, critical point theory ...
Wei-Shih Du
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Existence of three solutions for higher order BVP with parameters via Morse theory
Electronic Journal of Differential Equations, 2016 We prove the existence of at least three solutions to a general Lidstone problem using the Morse Theory.
Mariusz Jurkiewicz, Bogdan Przeradzki
doaj