Results 111 to 120 of about 3,726,336 (290)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A perspective on the contributions of Alan C. Lazer to critical point theory
Electronic Journal of Differential Equations, 2000 Over the last thirty five years Professor Alan C. Lazer has been a leading figure in the development of min-max methods and critical point theory for applications to partial differential equations.
Alfonso Castro
doaj
SciPost PhysicsWe set up an effective field theory formulation for the renormalization flow of matrix product states (MPS) with finite bond dimension, focusing on systems exhibiting finite-entanglement scaling close to a conformally invariant critical fixed point.
Jan T. Schneider, Atsushi Ueda, Yifan Liu, Andreas M. Läuchli, Masaki Oshikawa, Luca Tagliacozzo
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Infinite dimensional extensions of the Landesman-Lazer theorem
Electronic Journal of Differential Equations, 2021 Martin Schechter
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Minimax principles for critical-point theory in applications to quasilinear boundary-value problems
Electronic Journal of Differential Equations, 2000 Using the variational method developed by the same author in [7], we establish the existence of solutions to the equation $-Delta_p u = f(x,u)$ with Dirichlet boundary conditions.
A. R. El Amrouss, M. Moussaoui
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Infinitely many positive solutions for p-Laplacian equations with singular and critical growth terms
Boundary Value ProblemsIn this paper, we study the existence of multiple solutions for the following nonlinear elliptic problem of p-Laplacian type involving a singularity and a critical Sobolev exponent { − Δ p u = u p ∗ − 1 + λ | u | γ − 1 u , in Ω , u = 0 , on ∂ Ω ...
Chen-Xi Wang, Hong-Min Suo
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AxiomsNonlinear analysis has widespread and significant applications in many areas at the core of many branches of pure and applied mathematics and modern science, including nonlinear ordinary and partial differential equations, critical point theory ...
Wei-Shih Du
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source