Results 91 to 100 of about 3,726,336 (290)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Range of semilinear operators for systems at resonance

Electronic Journal of Differential Equations, 2012
For a vector function $u:mathbb{R} o mathbb{R}^N $ we consider the system $$displaylines{ u''(t)+ abla G(u(t))= p(t)cr u(t)=u(t+T), }$$ where $G: mathbb{R}^N o mathbb{R}$ is a $C^1$ function.
Pablo Amster, Mariel Paula Kuna
doaj  

Critical analysis of the theory of movement in movement in Allameh Tabatabai's view point [PDF]

تاریخ فلسفه اسلامی
Sadr al-Matahin proposed the movement in the category of substance by proposing the theory of substance movement. But he, like other philosophers, did not accept the movement in other categories, especially in categories whose individuals are gradually ...
Abdollah Nasri, Zeynab Yousofzadeh
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Heteroclinic orbits of a second order nonlinear difference equation

Electronic Journal of Differential Equations, 2017
This article concerns a second-order nonlinear difference equation. By using critical point theory, the existence of two heteroclinic orbits is obtained. The main method used is variational.
Haiping Shi, Xia Liu, Tao Zhou
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A modified zero energy critical point theory with applications to several nonlocal problems

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we devote ourselves to considering a modified zero energy critical point theory for a specific set of functionals denoted as $\Phi_{\mu}$, defined within the confines of a uniformly convex Banach space.
Xinzhong Liang, Binlin Zhang
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Critical point theory for symmetries with fixed points

, 2010
Gegenstand der Arbeit ist die Suche nach kritischen Punkten einer stetig differenzierbarer Funktion f auf einer Banach-Mannigfaltigkeit X, die invariant unter der Wirkung einer (kompakten Lie-) Symmetriegruppe G ist. Es gebe eine kompakte G-Mannigfaltigkeit M und eine G-äquivariante Surjektion von X auf M mit einem G-äquivarianten Schnitt, so dass sich
Born, Stefan, Justus Liebig University Giessen   +1 more
openaire   +3 more sources