Results 81 to 90 of about 419,462 (262)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A perspective on the contributions of Alan C. Lazer to critical point theory
Electronic Journal of Differential Equations, 2000 Over the last thirty five years Professor Alan C. Lazer has been a leading figure in the development of min-max methods and critical point theory for applications to partial differential equations.
Alfonso Castro
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
SciPost PhysicsWe set up an effective field theory formulation for the renormalization flow of matrix product states (MPS) with finite bond dimension, focusing on systems exhibiting finite-entanglement scaling close to a conformally invariant critical fixed point.
Jan T. Schneider, Atsushi Ueda, Yifan Liu, Andreas M. Läuchli, Masaki Oshikawa, Luca Tagliacozzo
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Variational Methods and Critical Point Theory 2013
Abstract and Applied Analysis, 2013 M. Victoria Otero-Espinar +3 more
doaj +1 more source
Infinite dimensional extensions of the Landesman-Lazer theorem
Electronic Journal of Differential Equations, 2021 Martin Schechter
doaj
A note on quasilinear elliptic eigenvalue problems
Electronic Journal of Differential Equations, 1999 We study an eigenvalue problem by a non-smooth critical point theory. Under general assumptions, we prove the existence of at least one solution as a minimum of a constrained energy functional. We apply some results on critical point theory with symmetry
Gianni Arioli
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source