Results 101 to 110 of about 450,232 (306)
Nonsmooth critical point theory and nonlinear elliptic equations at resonance [PDF]
, 2000 Papageorgiou, NS +3 more
core +1 more source
Critical point theory of symmetric functions and closed geodesics
, 1996 We develop a version of equivariant critical point theory particularly adapted to finding closed geodesics by variational methods and use it to improve the known lower bounds for the number of “short” closed geodesics on some closed Riemannian ...
Clapp, Mónica, Puppe, Dieter
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Resonant nonlinear periodic problems with the scalar p-Laplacian and a nonsmooth potential
, 2006 We study periodic problems driven by the scalar p-Laplacian with a nonsmooth potential. Using the nonsmooth critical point theory for locally Lipsctiz functions,we prove two existence theorems under conditions of resonance at infinity with respect to ...
Staicu, Vasile +6 more
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Perturbations of critical values in nonsmooth critical point theory
, 1996 Several theorems about the perturbation of critical values for continuous functionals are proved. Their applications to eigenvalue problems for variational inequalities are given.
DEGIOVANNI M., LANCELOTTI, SERGIO
openaire +3 more sources
Relative homological linking in critical point theory
, 2007 A relative homological linking of pairs is proposed. It is shown to imply homotopical linking, as well as earlier non-relative notion of homological linkings.
Girouard, Alexandre
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source