Results 61 to 70 of about 13,119,461 (251)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Critical Point Theorems and Ekeland Type Variational Principle with Applications [PDF]
, 2011 [[abstract]]We introduce the notion of λ-spaces which is much weaker than cone metric spaces defined by Huang and X. Zhang (2007). We establish some critical point theorems in the setting of λ-spaces and, in particular, in the setting of complete cone ...
L. J. Lin; Sung Yu Wang;Q. H. Ansari
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Periodic solutions for second order delay Duffing equation via critical point theory
Electronic Journal of Differential Equations, 2013 This article concerns the periodic problem of second order delay Duffing equation with cross resonance condition. Using critical point theory and homotopy methods, we obtain sufficient conditions for the existence of periodic solutions.
Jingrui Zhang, Yi Cheng, Changqin Yuan
doaj
Boundary Value ProblemsThis paper is devoted to the study of a mixed boundary value problem for a complete Sturm–Liouville equation, where the coefficients can also be negative. In particular, the existence of infinitely many distinct positive solutions to the given problem is
Gabriele Bonanno +2 more
doaj +1 more source
Theory of the Many-Body Localization Transition in One-Dimensional Systems
Physical Review X, 2015 We formulate a theory of the many-body localization transition based on a novel real-space renormalization group (RG) approach. The results of this theory are corroborated and intuitively explained with a phenomenological effective description of the ...
Ronen Vosk, David A. Huse, Ehud Altman
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Critical multiculturalism: theory and praxis
, 2010 Content: Introduction. Critical Multiculturalism: Theory and Praxis / Stephen May and Christine E. Sleeter -- Pt. I. Critical Multiculturalism and Teachers -- Pt. II. Critical Multiculturalism in Language and Language Arts -- Pt. III.
Sleeter, C, May, Stephen
core
Morse Thoery of Saddle Point Reduction with Applications
AxiomsIn this paper, we demonstrate that when saddle point reduction is applicable, there is a clear relationship between the Morse index and the critical groups before and after the reduction.
Ran Yang, Qin Xing
doaj +1 more source