Results 61 to 70 of about 450,232 (306)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Periodic solutions for second order delay Duffing equation via critical point theory
Electronic Journal of Differential Equations, 2013 This article concerns the periodic problem of second order delay Duffing equation with cross resonance condition. Using critical point theory and homotopy methods, we obtain sufficient conditions for the existence of periodic solutions.
Jingrui Zhang, Yi Cheng, Changqin Yuan
doaj
Boundary Value ProblemsThis paper is devoted to the study of a mixed boundary value problem for a complete Sturm–Liouville equation, where the coefficients can also be negative. In particular, the existence of infinitely many distinct positive solutions to the given problem is
Gabriele Bonanno +2 more
doaj +1 more source
Critical Point Theorems and Ekeland Type Variational Principle with Applications
, 2011 [[abstract]]We introduce the notion of λ-spaces which is much weaker than cone metric spaces defined by Huang and X. Zhang (2007). We establish some critical point theorems in the setting of λ-spaces and, in particular, in the setting of complete cone ...
L. J. Lin; Sung Yu Wang;Q. H. Ansari
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Morse Thoery of Saddle Point Reduction with Applications
AxiomsIn this paper, we demonstrate that when saddle point reduction is applicable, there is a clear relationship between the Morse index and the critical groups before and after the reduction.
Ran Yang, Qin Xing
doaj +1 more source
The Set-Point Theory of Well-Being Needs Replacing: On the Brink of a Scientific Revolution? [PDF]
Set-point theory has dominated the field of subjective well-being (SWB). It has served as a classic Kuhn research paradigm, being extended and refined for thirty years totake in new results. The central plank of the theory is that adult set-points do not
Bruce Headey
core
Talk the talk, walk the walk: Defining Critical Race Theory in research [PDF]
, 2012 Over the last decade there has been a noticeable growth in published works citing Critical Race Theory (CRT). This has led to a growth in interest in the UK of practical research projects utilising CRT as their framework.
Hylton, K, Kevin Hylton
core +1 more source