Results 61 to 70 of about 419,462 (262)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Range of semilinear operators for systems at resonance
Electronic Journal of Differential Equations, 2012 For a vector function $u:mathbb{R} o mathbb{R}^N $ we consider the system $$displaylines{ u''(t)+ abla G(u(t))= p(t)cr u(t)=u(t+T), }$$ where $G: mathbb{R}^N o mathbb{R}$ is a $C^1$ function.
Pablo Amster, Mariel Paula Kuna
doaj
A modified zero energy critical point theory with applications to several nonlocal problems
Electronic Journal of Qualitative Theory of Differential EquationsIn this paper, we devote ourselves to considering a modified zero energy critical point theory for a specific set of functionals denoted as $\Phi_{\mu}$, defined within the confines of a uniformly convex Banach space.
Xinzhong Liang, Binlin Zhang
doaj +1 more source
Critical analysis of the theory of movement in movement in Allameh Tabatabai's view point [PDF]
تاریخ فلسفه اسلامیSadr al-Matahin proposed the movement in the category of substance by proposing the theory of substance movement. But he, like other philosophers, did not accept the movement in other categories, especially in categories whose individuals are gradually ...
Abdollah Nasri, Zeynab Yousofzadeh
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Heteroclinic orbits of a second order nonlinear difference equation
Electronic Journal of Differential Equations, 2017 This article concerns a second-order nonlinear difference equation. By using critical point theory, the existence of two heteroclinic orbits is obtained. The main method used is variational.
Haiping Shi, Xia Liu, Tao Zhou
doaj
Critical Point Theory for the Lorentz Force Equation
Archive for Rational Mechanics and Analysis, 2019 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
David Arcoya +2 more
openaire +3 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Critical Point Theory for Indefinite Functionals with Symmetries
Journal of Functional Analysis, 1996 Let \(X\) be a Hilbert space and \(G\) a compact Lie group acting orthogonally on \(X\). Let \(\phi \in C^1(X,\mathbb{R})\) be a strongly indefinite functional, invariant with respect to the action of \(G\). In order to find critical points of \(\phi\), the authors introduce an equivariant version of the limit relative category of \textit{G.
Bartsch, Thomas, Clapp, Mónica
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source