Results 51 to 60 of about 13,119,461 (251)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Multiple Solutions for a Nonlinear Fractional Boundary Value Problem via Critical Point Theory
Journal of Function Spaces, 2017 This paper is concerned with the existence of multiple solutions for the following nonlinear fractional boundary value problem: DT-αaxD0+αux=fx,ux, x∈0,T, u0=uT=0, where α∈1/2,1, ax∈L∞0,T with a0=ess infx∈0,Tax>0, DT-α and D0+α stand for the left and ...
Yang Wang, Yansheng Liu, Yujun Cui
doaj +1 more source
Periodic solutions to a class of distributed delay differential equations via variational methods
Advances in Nonlinear Analysis, 2023 In this article, we study the existence of periodic solutions to a class of distributed delay differential equations. We transform the search for periodic solutions with the special symmetry of a delay differential equation to the problem of finding ...
Xiao Huafeng, Guo Zhiming
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Surveillance and critical theory [PDF]
, 2015 In this comment, the author reflects on surveillance from a critical theory approach, his involvement in surveillance research and projects, and the status of the study of surveillance.
Fuchs, Christian
core
Sign-changing solutions for some nonlinear problems with strong resonance
Boundary Value Problems, 2011 By means of critical point and index theories, we obtain the existence and multiplicity of sign-changing solutions for some elliptic problems with strong resonance at infinity, under weaker conditions.
Qian Aixia
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
, 2011 Many partial differential equations arising in Physics can be seen as innite dimensional Hamiltonian systems. Main examples are the nonlinear Schrodinger (NLS) and wave (NLW) equations, the beam, membrane and Kirkhoff equations in elasticity theory, the ...
BERTI, MASSIMILIANO
core
Sing-changing solutions for nonlinear problems with strong resonance
Electronic Journal of Differential Equations, 2012 Using critical point theory and index theory, we prove the existence and multiplicity of sign-changing solutions for some elliptic problems with strong resonance at infinity, under weaker conditions than in the references.
Aixia Qian
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source