Results 41 to 50 of about 14,205,522 (247)
Once an obscure academic concept, the term critical race theory (CRT) has become a regular fixture in mainstream media and social media as well as local school board meetings.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Entanglement and Chaos near critical point in strongly coupled Gauge theory
We perform a holographic study of the high and low temperature behaviours of logarithmic negativity (LN) and entanglement wedge cross section (EWCS) in a large N strongly coupled thermal field theory with critical point, having a well defined gravity ...
Debanjan Karan, Sanjay Pant
doaj +1 more source
Holographic entanglement of purification near a critical point
In the presence of finite chemical potential $$\mu $$ μ , we holographically compute the entanglement of purification in a $$2+1$$ 2 + 1 - and $$3+1$$ 3 + 1 -dimensional field theory and also in a $$3+1$$ 3 + 1 -dimensional field theory with a critical ...
B. Amrahi, M. Ali-Akbari, M. Asadi
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The longue duree of community engagement: New applications of critical theory in planning research [PDF]
Habermas' critical theory, and particularly his theory of communicative action, has been applied in the theory and practice of communicative planning. The concept of creating a public sphere in planning processes has been used as an ‘ought' that ...
Matthews, P., Matthews, Peter
core +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source

