Results 71 to 80 of about 13,119,461 (251)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Existence of homoclinic orbits for a class of nonlinear functional difference equations
Electronic Journal of Differential Equations, 2016 By using critical point theory, we prove the existence of a nontrivial homoclinic orbit for a class of nonlinear functional difference equations. Our conditions on the nonlinear term do not need to satisfy the well-known global Ambrosetti-Rabinowitz ...
Xia Liu, Tao Zhou, Haiping Shi
doaj
Bulletin of Mathematical SciencesDue to the essential difficulty of establishing an appropriate variational framework on a suitable working space, how to apply the critical point theory for showing the existence and multiplicity of periodic solutions of continuous-time difference ...
Genghong Lin +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Destabilizing the Activity System of Online Teaching Through Critical Theory
, 2018 Despite the rapid and prolific uptake of online learning across higher education, the promised positive impact of digital technologies on the quality of learning has mostly failed to materialize.
Wang, VCX +5 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Freedom of Speech in the Woke Era: Critical Race Theory and State Neutrality
, 2023 This article considers freedom of speech in light of current debates regarding the banning of symbols some might find offensive and/or hurtful. It considers critical race theory as an example of postmodernism, and its demands for an end to state ...
Gray, Anthony
core +1 more source
Multiplicity of Homoclinic Solutions for Fractional Hamiltonian Systems with Subquadratic Potential
Entropy, 2017 In this paper, we study the existence of homoclinic solutions for the fractional Hamiltonian systems with left and right Liouville–Weyl derivatives. We establish some new results concerning the existence and multiplicity of homoclinic solutions for the ...
Neamat Nyamoradi +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source