Results 71 to 80 of about 3,726,336 (290)

Existence of Solutions for Higher Order Bvp with Parameters via Critical Point Theory

Demonstratio Mathematica, 2015
This paper is concerned with the existence of at least one solution of the nonlinear 2k-th order BVP. We use the Mountain Pass Lemma to get an existence result for the problem, whose linear part depends on several parameters.
Jurkiewicz Mariusz, Przeradzki Bogdan
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Multiple Solutions for a Nonlinear Fractional Boundary Value Problem via Critical Point Theory

Journal of Function Spaces, 2017
This paper is concerned with the existence of multiple solutions for the following nonlinear fractional boundary value problem: DT-αaxD0+αux=fx,ux,  x∈0,T, u0=uT=0, where α∈1/2,1, ax∈L∞0,T with a0=ess  infx∈0,Tax>0, DT-α and D0+α stand for the left and ...
Yang Wang, Yansheng Liu, Yujun Cui
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Periodic solutions for second order delay Duffing equation via critical point theory

Electronic Journal of Differential Equations, 2013
This article concerns the periodic problem of second order delay Duffing equation with cross resonance condition. Using critical point theory and homotopy methods, we obtain sufficient conditions for the existence of periodic solutions.
Jingrui Zhang, Yi Cheng, Changqin Yuan
doaj  

Spin glass transition in a magnetic field: a renormalization group study

, 2002
We study the transition of short range Ising spin glasses in a magnetic field, within a general replica symmetric field theory, which contains three masses and eight cubic couplings, that is defined in terms of the fields representing the replicon ...
A. J. Bray, A.B. Harris, A.J. Bray, A.J. Bray, C. De Dominicis, C. De Dominicis, D. Sherrington, D.S. Fisher, D.S. Fisher, E. Pytte, F. Krzakala, G. Parisi, G. Parisi, G. Parisi, G. Parisi, G. Parisi, I. R. Pimentel, J. Houdayer, J.E. Green, J.R.L. de Almeida, K. Binder, K.G. Wilson, P. Monod, S.F. Edwards, T. Temesvari, T. Temesvári, W.L. McMillan   +26 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mixed boundary value problems involving Sturm–Liouville differential equations with possibly negative coefficients

Boundary Value Problems
This paper is devoted to the study of a mixed boundary value problem for a complete Sturm–Liouville equation, where the coefficients can also be negative. In particular, the existence of infinitely many distinct positive solutions to the given problem is
Gabriele Bonanno, Giuseppina D’Aguì, Valeria Morabito   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source