Results 191 to 200 of about 1,797,780 (305)

On critical points of Gaussian random fields under diffeomorphic transformations. [PDF]

Stat Probab Lett, 2020
Cheng D, Schwartzman A.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Management of Therapeutic-intensity Unfractionated Heparin: A Narrative Review on Critical Points. [PDF]

TH Open
Gouin-Thibault I, Mansour A, Hardy M, Guéret P, de Maistre E, Siguret V, Cuker A, Mullier F, Lecompte T.   +8 more
europepmc   +1 more source

Estimation of the critical points of an epidemic by means of a logistic growth model

, 2021
Allaman IB, Jelihovschi EG.
europepmc   +1 more source

Crystal Memory near Discontinuous Triacylglycerol Phase Transitions: Models, Metastable Regimes, and Critical Points. [PDF]

Molecules, 2020
Pink DA, Ladd-Parada M, Marangoni AG, Mazzanti G.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Open micro-combinatorial analysis systems of crystal growth critical points of a π-conjugated molecule in ionic liquid nanoliter droplets. [PDF]

RSC Adv
Watanabe S, Inouchi S, Kunitake M.
europepmc   +1 more source

State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia. [PDF]

Cancer Res, 2020
Rockne RC, Branciamore S, Qi J, Frankhouser DE, O'Meally D, Hua WK, Cook G, Carnahan E, Zhang L, Marom A, Wu H, Maestrini D, Wu X, Yuan YC, Liu Z, Wang LD, Forman S, Carlesso N, Kuo YH, Marcucci G.   +19 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stability of vitamin A at critical points in pet-feed manufacturing and during premix storage. [PDF]

Front Vet Sci
Galli GM, Andretta I, Martinez N, Wernick B, Shastak Y, Gordillo A, Gobi J.   +6 more
europepmc   +1 more source