Results 181 to 190 of about 8,524,171 (298)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Critical Points in the Noiseberg Achievable Region of the Gaussian Z-Interference Channel. [PDF]

Entropy (Basel)
Costa MHM, Nair C, Ng D.
europepmc   +1 more source

Critical Points on the Use of Biologicals in Allergic Diseases and Asthma. [PDF]

Allergy Asthma Immunol Res, 2020
Agache I, Cojanu C, Laculiceanu A, Rogozea L.   +3 more
europepmc   +1 more source

Exploring the critical points of teaching STEM subjects in the time of COVID 19: the experience of the course "Microscopy Techniques for Forensic Biology". [PDF]

F1000Res, 2021
Brunelli E, Macirella R.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Critical Points of Risk in Registered Nurses' Use of a National Early Warning Score-Perceptions and Challenges. [PDF]

J Adv Nurs
Nadaf C, Bench S, Halpin Y, Terry L.
europepmc   +1 more source

Temperature dependence of the dielectric function and critical points of α-SnS from 27 to 350 K. [PDF]

Sci Rep, 2020
Nguyen HT, Le VL, Nguyen TMH, Kim TJ, Nguyen XA, Kim B, Kim K, Lee W, Cho S, Kim YD.   +9 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Long-term biological surveillance of SARS-CoV-2 in critical points for municipal sewage catchment in light of wastewater-based epidemiology, public health and environmental hygiene. [PDF]

Sci Rep
Korzekwa K, Lepionka T, Bisak A, Obuch-Woszczatyńska O, Bylińska K, Kauc A, Skuza K, Zaborski B, Krzyżowska M.   +8 more
europepmc   +1 more source

On critical points of Gaussian random fields under diffeomorphic transformations. [PDF]

Stat Probab Lett, 2020
Cheng D, Schwartzman A.
europepmc   +1 more source