Results 161 to 170 of about 8,524,171 (298)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Open-Microcombinatorial Analysis of Critical Points of Crystal Growth and Nucleation for Small Molecules in Organic Solvents. [PDF]

ACS Omega
Watanabe S, Masunaga S.
europepmc   +1 more source

Asymptotically critical points and their multiplicity

, 2002
In this paper we study multiplicity results for the critical points of a functional via topological information which ensures multiplicity of critical points for a sequence of approximating functionals. The main statement is quite simple, and it seems it
MUGNAI D., Mugnai, Dimitri, MARINO, ANTONIO   +2 more
core  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Critical points of multiple defenses and system resilience reconstruction: a QCA configuration analysis and governance implications of maritime accidents. [PDF]

Front Public Health
Li M.
europepmc   +1 more source

Critical points and effectiveness of prophylactic C4/5 foraminotomy to prevent C5 palsy after posterior cervical spine surgery. [PDF]

Acta Orthop Traumatol Turc, 2021
Takeuchi K, Yokoyama T, Wada K, Kumagai G, Sasaki E, Ishibashi Y.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Using critical points of logistic model to describe the growth of rice plant height in Taiwan. [PDF]

Sci Rep
Hsieh CY, Chen H, Wu YC, Teng CY, Li CH.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A case study of critical points for the entry and spread of Salmonella Infantis in a broiler farm. [PDF]

Ir Vet J
Papić B, Mićunović J, Slavec B, Šemrov N, Zorman Rojs O, Avberšek J.   +5 more
europepmc   +1 more source