Results 81 to 90 of about 1,606,935 (294)

Construction and validation of an Instrument for the evaluation of Critical Thinking in Family Leisure Decision offline and online (ICT_FLD)

RED. Revista de Educación a Distancia
Families' critical thinking about shared leisure, both offline and online, influences the quality of family dynamics and the socio-educational development of children.
Natalia González-Fernández, Elena Briones Pérez, Irina Salcines-Talledo, Fernando Martínez-Abad   +3 more
doaj   +1 more source

Eliciting usage contexts of safety-critical medical devices [PDF]

, 2014
This position paper outlines our approach to improve the usage choice of suitable devices in different health care environments (contexts). Safety-critical medical devices are presumed to have undergone a thorough (user-centred) design process to ...
Reeves, Steve, Jung, Doris, Hinze, Annika, Bowen, Judy, Cunningham, Sally Jo   +4 more
core  

A Critical Review of Properties of Darunavir and Analytical Methods for Its Determination [PDF]

, 2014
Darunavir is a synthetic non-peptidic protease inhibitor that has been shown to be extremely potent against wild-type HIV, and it is an important component of highly active antiretroviral treatment (HAART), which is considered as one of the most ...
Salgado, Hérida Regina Nunes [UNESP], Deirdre M. D’Arcy, Salgado, Hérida Regina Nunes, Hérida Regina Nunes Salgado, Reis Serra, Cristina Helena dos, Ruela Correa, Josilene Chaves, D'Arcy, Deirdre M., Josilene Chaves Ruela Corrêa, Cristina Helena dos Reis Serra, Ruela Correa, Josilene Chaves [UNESP]   +9 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Automated identification of safety-critical attacks against CPS and generation of assurance case fragments [PDF]

Ensuring the safety of cyber-physical systems (CPS) against cyber security threats is essential in safety-critical sectors. To this end, the systematic derivation of clear and robust safety claims is needed to demonstrate that safety properties are ...
Guerra, Sofia, Lupu, Emil, Castiglione, Luca   +2 more
core  

Critical Properties of Metal-Containing Ionic Liquids [PDF]

, 2019
A group contribution method developed by Valderrama and Robles in 2007 is updated and extended to calculate the critical properties, the normal boiling temperature, and the acentric factor of metal-containing ionic liquids (MILs).
José O. Valderrama (1622860), Luis A. Forero (1622854), Roberto E. Rojas (2076703)   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Critical properties of NaCI-H₂O Solutions [PDF]

, 2013
Critical properties of the NaCI-H₂0 fluid system are of fundamental interest to a variety of geochemical applications including fluid inclusion studies, numerical modeling of hydrothermal systems, and development of theoretical models for two·component ...
Knight, Cheryl L. Erickson
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Critical properties of random magnetic systems [PDF]

, 1979
A review of the recent applications of renormalisation group techniques to the calculations of the critical properties of random magnetic systems is ...
Deepak Kumar,
core   +1 more source