Results 121 to 130 of about 5,968,098 (330)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Crítica e cultura em marketing: repensando a disciplina

Cadernos EBAPE.BR
Este artigo descreve o processo de implementação de uma abordagem crítica em marketing, baseada no realismo crítico e desenvolvida na Inglaterra e no Brasil por um pesquisador brasileiro.
Alexandre Faria
doaj   +1 more source

Left Realism: A Radical Criminology for the Current Crisis

International Journal for Crime, Justice and Social Democracy, 2016
The renewal of the Left realist tradition in criminology is vital for a critical understanding of crime and criminal justice in the context of a dominant neoliberalism. Left Realism presented two core components: the local democratic community control of
John Lea
doaj   +1 more source

Covid, critical realism and category-mistake. [PDF]

Int J Health Plann Manage, 2022
Paton C.
europepmc   +1 more source

Critical Realism in Economics and Open-Systems Ontology: A Critique [PDF]

This paper examines the treatment of ontology offered by Critical Realism. Three main criticisms are made of the Critical Realist treatment of open systems.
Andrew Mearman
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Beyond Capitalist Realism – Why We Need Critical Future Studies

Culture Unbound: Journal of Current Cultural Research, 2017
This paper introduces the interdisciplinary field of Critical Future Studies (CFS). CFS investigates the scope and constraints within public culture for imagining and debating different potential futures.
Luke Goode, Michael Godhe
doaj   +2 more sources

Critical Realism: Philosophical Origin and Methodological Principles [PDF]

Islām va ̒ulūm-i ijtimā̒ī
During the past few decades, social sciences and humanities has been involved in numerous methodological and theoretical debates that is described as the paradigms war between positivists, interpretativists and critics.
Ahmad Mohammad Poor, Mahdi Alizadeh, Mahdi Rezayee   +2 more
doaj  

Asking “How” and “Why” and “Under What Conditions” Questions: Using Critical Realism to Study Learning and Teaching

Teaching & Learning Inquiry: The ISSOTL Journal
Research paradigms offer a way for scholars to design, communicate, and reflect on their research effectively. A paradigm encapsulates the researcher’s worldview, including the epistemology, ontology, and axiology of the research.
Janice Miller-Young
doaj   +1 more source

Aristotle, Dialectic and Critical Realism [PDF]

, 2009
This paper sets out to show that central aspects of Aristotle’s view of science are of continued contemporary relevance. It argues that a widespread failure to recognise this derives, in part, from a continued commitment to Humean ideas. And it shows how
Mann, Scott
core