Results 151 to 160 of about 11,999,161 (302)

Bridging equity, empathy, and evidence in NEET-UG reform: A critical response. [PDF]

J Family Med Prim Care
Shaikh SJ, Srivastava K, Patole IM.
europepmc   +1 more source

The Critical Response Team in Airway Emergencies. [PDF]

Perm J, 2019
Damrose JF, Eropkin W, Ng S, Cale S, Banerjee S.   +4 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A critical response to recent publications on gender affirming care. [PDF]

Australas Psychiatry
Gonçalves CC, Milicevic M, Yung AR.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Rethinking child safety in community-based health programmes: A critical response to parents' perceptions of health coordinators. [PDF]

Public Health Pract (Oxf)
Ulfah, Suhardita K, Dharmayanti PA, Widana IW, Saputra R, Ramadhani E, Datuti S, Arizona, Pohan RA, Soejanto LT, Dharma Tari IDAEP, Badriyah RDU.   +11 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Critical Response to the Comments on the Critical Issue of Infant and Child Mortality in Afghanistan. [PDF]

Health Sci Rep
Lippi G, Mattiuzzi C.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Response to Letter to Editor "Critical Response to the Comments on the Critical Issue of Infant and Child Mortality in Afghanistan". [PDF]

Health Sci Rep
Chirumbolo S.
europepmc   +1 more source