Results 191 to 200 of about 6,939,801 (335)

When Did I Begin? Another Critical Response to Norman Ford [PDF]

, 1991
Flaman, Paul
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Nonlinear amplification of nano bowl surface concavity on the critical response threshold to biosignals. [PDF]

Nat Commun
Li X, Liang X, Yang C, Yan Q.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Identification of the AHP family reveals their critical response to cytokinin regulation during adventitious root formation in apple rootstock. [PDF]

Front Plant Sci
Li K, Li H, Liang WL, Liu JJ, Tian HY, Wang LH, Wei YH.   +6 more
europepmc   +1 more source

Prevention and Response to Sexual and Gender-Based Violence in Conflict North-Eastern Nigeria: A Critical Review of the Engagement Mechanisms of Communities Based Protection Committees [PDF]

Daniel Onyedika Ugwuanyi, Shulamite Ebere Ogbuabor, Justice Chukwudi Ulunta   +2 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

On the nature of signal 1 delivered to lymphocytes: A critical response to some considerations put forward in support of the quantum model of T cell activation. [PDF]

Scand J Immunol
Bretscher PA.
europepmc   +1 more source

Extraordinary 2021 snowstorm in Spain reveals critical threshold response to anthropogenic climate change [PDF]

Damián Insúa-Costa, Marc Lemus‐Canovas, Juan Jesús González‐Alemán, Martín Senande-Rivera, María Carmen Llasat, Gonzalo Miguez‐Macho, Diego G. Miralles   +6 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source