Results 41 to 50 of about 6,950,475 (283)

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Revisiting Bob Dylan’s Tarantula in a Rough and Rowdy Time

Intersections, 2020
For over half a century, Bob Dylan has held what Ben Sisario of the New York Times calls “an almost mythic status as the bard of the current age.” Yet one can argue that the “current age” might well be every age.
Sarah Hillenbrand Varela
doaj   +1 more source

Splenic trauma in the Northern Territory; the impact of an interventional radiology service on splenic trauma management and outcomes

Heliyon, 2023
Background: The spleen is the most commonly injured organ in abdominal trauma. Guidelines suggest non-operative management (NOM) is preferred over splenectomy for all haemodynamically stable patients, regardless of injury severity.
Ashleigh Spittle, Alex Britcliffe, Mark Joh Hamilton   +2 more
doaj   +1 more source

Non-linear Elastic Response in Solid Helium: critical velocity or strain

, 2010
Torsional oscillator experiments show evidence of mass decoupling in solid 4He. This decoupling is amplitude dependent, suggesting a critical velocity for supersolidity. We observe similar behavior in the elastic shear modulus.
A. S. Nowick, James Day, John Beamish, Oleksandr Syshchenko   +3 more
core   +1 more source

Crack propagation in honeycomb cellular materials: a computational approach [PDF]

, 2012
Computational models based on the finite element method and linear or nonlinear fracture mechanics are herein proposed to study the mechanical response of functionally designed cellular components. It is demonstrated that, via a suitable tailoring of the
Paggi, Marco
core   +2 more sources

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Thromboelastography Parameters and Platelet Count on Admission to the ICU and the Development of Venous Thromboembolism in Patients With Coronavirus Disease 2019

Critical Care Explorations, 2021
Objectives:. Determine if thromboelastography parameters and platelet count on the day of ICU admission are associated with the development of venous thromboembolism in patients with coronavirus disease 2019. Design:.
Tanya K. Marvi, MD, William B. Stubblefield, MD, Benjamin F. Tillman, MD, Mark W. Tenforde, MD, PhD, Leora R. Feldstein, PhD, MSc, Manish M. Patel, MD, Wesley H. Self, MD, MPH, Carlos G. Grijalva, MD, MPH, Todd W. Rice, MD, MSc, For the Influenza Vaccine Effectiveness in the Critically Ill (IVY) Investigators   +9 more
doaj   +1 more source

Coexistence of critical sensitivity and subcritical specificity can yield optimal population coding

, 2017
The vicinity of phase transitions selectively amplifies weak stimuli, yielding optimal sensitivity to distinguish external input. Along with this enhanced sensitivity, enhanced levels of fluctuations at criticality reduce the specificity of the response.
Gollo, Leonardo L.
core   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source