Results 41 to 50 of about 2,765,545 (264)

Host Response and Hemodynamics

Xiehe Yixue Zazhi, 2022
With the continuous exploration of the pathophysiological mechanisms of critical illness, the host response, a 'bridge' between different etiologies and the development of critical illness, has received much attention.
WANG Guangjian, WANG Xiaoting
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Fake Majority:

La Revista Icono 14
Purpose: This study explores how perceived astroturfing and media literacy influence individuals’ critical responses to online content. It examines whether awareness of astroturfing and self-reported evaluation style mediate this relationship ...
Tanase Tasente, Cristina-Dana Popescu
doaj   +1 more source

Hospital preparedness for mass critical care during SARS-CoV-2 pandemic

Critical Care, 2020
Mass critical care caused by the severe acute respiratory syndrome corona virus 2 pandemic poses an extreme challenge to hospitals. The primary goal of hospital disaster preparedness and response is to maintain conventional or contingency care for as ...
Thomas Wurmb, Katja Scholtes, Felix Kolibay, Nora Schorscher, Georg Ertl, Ralf-Ingo Ernestus, Ulrich Vogel, Axel Franke, Barbara Kowalzik   +8 more
doaj   +1 more source

A one-year follow-up study of systematic impact of long COVID symptoms among patients post SARS-CoV-2 omicron variants infection in Shanghai, China

Emerging Microbes and Infections, 2023
Long COVID hinders people from normal life and work, posing significant medical and economic challenges. Nevertheless, comprehensive studies assessing its impact on large populations in Asia are still lacking.
Jianpeng Cai, Ke Lin, Haocheng Zhang, Quanlin Xue, Kun Zhu, Guanmin Yuan, Yuhan Sun, Feng Zhu, Jingwen Ai, Sen Wang, Wenhong Zhang   +10 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Incidental Detection of Asymptomatic Upper Extremity Deep Vein Thrombosis in an Elderly Patient With Pulmonary Embolism

Acute Medicine & Surgery
Background Upper extremity deep vein thrombosis (UEDVT) is rare, accounting for 4%–10% of all DVT cases. Central venous catheterization and malignancy are primary risk factors, making cases without these factors uncommon.
Shuhei Uotani, Yoshihiro Aoki, Keita Iyama, Atsuko Tachikawa, Daisuke Sugawara, Kensuke Takahashi, Shuhei Yamano, Koichi Hayakawa, Osamu Tasaki   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source