Results 71 to 80 of about 2,782,952 (263)

A chronic whole cigarette smoke extract model reveals redox–mitochondrial adaptation in human lung epithelial and organoid models

Experimental and Molecular Medicine
Cigarette smoke (CS) imposes continuous oxidative and electrophilic stress that disrupts cellular homeostasis in the lung. While acute smoking exposure induces transient antioxidant responses, how the epithelial system adapts to chronic smoke remains ...
Joo-Eun Lee, Dahye Lee, Jihyun Lee, Sung-Joon Han, Sung Hyun Kang, Ryeo-Eun Go, Jihyun Kwon, Younjhin Ahn, Mi Jung Lim, Mahn Jae Lee, Hee Min Yoo, Da Hyun Kang, Jeong Eun Lee, Dongil Park, Chaeuk Chung   +14 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Case Report: Successful avoidance of etoposide for primary hemophagocytic lymphohistiocytosis-induced multiple organ dysfunction syndrome using emapalumab

Frontiers in Pediatrics
We describe the case of an infant who presented with simple rhinovirus/enterovirus bronchiolitis whose condition worsened with rapid progression to multiple organ dysfunction syndrome (MODS).
Timothy J. Hahn, Timothy J. Hahn, Daniel J. McKeone, Daniel J. McKeone, James W. Beal, Jessica E. Ericson, Jessica E. Ericson, E. Scott Halstead, E. Scott Halstead   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Reading Response in Mary Balogh: A Critical Engagement

Journal of Popular Romance Studies, 2021
A long established author of Regency-set romances, Mary Balogh has a history of subverting the trends and tropes of the genre. This paper examines how Balogh uses subversion as a form of participating in the critical discussion on romance novels that ...
Veera Mäkelä
doaj  

Critical Response

, 2022
Among the papers this response is concerned with, two are dedicated to Tibetan Buddhism. Lobsang Dargyay’s paper deals with a crucial theoretical problem of the Buddhist karma theory — the connection between the past deed and its fruition at a much later time in the framework of an antisubstantialist ontology — in the philosophy of Tsong-kha-pa (1357 ...
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Another potential etiology for cardiac manifestation after snakebite

Tropical Medicine and Health
This letter discusses the possibility of Takotsubo cardiomyopathy (TTC) as an alternative diagnosis in a recently reported case of acute myocardial infarction following a hump-nosed viper bite.
Yoshihiro Aoki, Chris Smith, Koya Ariyoshi   +2 more
doaj   +1 more source