Results 91 to 100 of about 6,302,669 (265)

Critical Slowing Down Reveals Hydrologic Resilience Loss Across Amazon Sub‐Basins

open access: yesWater Resources Research
The Amazon's hydroclimate exhibits basin‐scale early‐warning signals of critical slowing down (CSD), a statistical signature of declining resilience as systems approach critical transitions.
Germán Poveda
doaj   +1 more source

Local nearby bifurcations lead to synergies in critical slowing down: the case of mushroom bifurcations [PDF]

open access: yes
The behavior of nonlinear systems near critical transitions has significant implications for stability, transients, and resilience in complex systems.
Sardanyés, Josep   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Asymptotic Behaviour for Critical Slowing-Down Random Walks [PDF]

open access: yesJournal of Statistical Physics, 2000
8 pages, 4 figures Brussels 1999 (G.
openaire   +3 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

open access: yesMolecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau   +9 more
wiley   +1 more source

A stochastic approach to the analysis of chemically reacting systems—IV. Critical slowing down in autocatalysis

open access: yes, 1985
The case of an autocatalytic reaction in the presence of fluctuations is analysed. The governing Fokker-Planck equation has been solved using three different methods.
Kulkarni, B. D.   +5 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Critical slowing down in networks generating temporal complexity

open access: yesPhysical Review E, 2015
We study a nonlinear Langevin equation describing the dynamic variable X(t), the mean field (order parameter) of a finite size complex network at criticality. The conditions under which the autocorrelation function of X shows any direct connection with criticality are discussed. We find that if the network is prepared in a state far from equilibrium, X(
M T, Beig   +4 more
openaire   +3 more sources

Critical Slowing Down of Cluster Algorithms for Ising Models Coupled to 2-d Gravity [PDF]

open access: yes, 1993
We simulate single and multiple Ising models coupled to 2-d gravity using both the Swendsen-Wang and Wolff algorithms to update the spins. We study the integrated autocorrelation time and find that there is considerable critical slowing down ...
Harris, Geoffrey   +7 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

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