Results 71 to 80 of about 6,302,669 (265)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Critical Slowing down of state relaxation during fate commitment.

, 2016
Apparent critical slowing down of relaxation and restoring of parental distribution of the sorted Sca1-low outlier fraction in the treated population.
Sui Huang (10384), Joseph Zhou (3603515), Rebecca Y. Y. Leong-Quong (3603512), Hannah Chang (3603518), Alessandro Giuliani (27508), Alexander Skupin (244450), Kalliopi Trachana (654377), Mitra Mojtahedi (3603509), Ivan G. Castaño (3603521)   +8 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A discrete-time benchmark for assessing critical slowing down indicators

Journal of Physics: Complexity
We introduce a low-dimensional, discrete-time benchmark for evaluating critical slowing down indicators and early-warning signals in the presence of complex dynamics.
Sajad Jafari, Anitha Karthikeyan, Mahtab Mehrabbeik, Karthikeyan Rajagopal, Veli Baysal, Matjaž Perc   +5 more
doaj   +1 more source

Critical slowing-down as indicator of approach to the loss of stability [PDF]

2014 IEEE International Conference on Smart Grid Communications (SmartGridComm), 2014
Shorter version submitted to IEEE SmartGridComm 2014; 6 pages, 4 figures, discussion of autostructure functions ...
Podolsky, Dmitry, Turitsyn, Konstantin
openaire   +5 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Criticality in the slowed-down boiling crisis at zero gravity [PDF]

Physical Review E, 2015
Boiling crisis is a transition between nucleate and film boiling. It occurs at a threshold value of the heat flux from the heater called CHF (critical heat flux). Usually, boiling crisis studies are hindered by the high CHF and short transition duration (below 1 ms).
Charignon, T, Lloveras, P, Chatain, D, Truskinovsky, L, Vives, E, Beysens, D, Nikolayev, Vadim   +6 more
openaire   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

A stochastic approach to the analysis of chemically reacting systems—III. Effect of fluctuations on critical slowing down

, 1985
The present paper examines the influence of inherent (internal) and random fluctuations on the phenomenon of critical slowing down. The analysis employs the Fokker-Planck equation derived from the master equation as well as the Langevin equation to ...
Kulkarni, B. D., L.K. Doraiswamy, S.S. Tambe, Tambe, S. S., B.D. Kulkarni, Doraiswamy, L. K.   +5 more
core   +1 more source