Results 61 to 70 of about 6,302,669 (265)

Vegetation greening does not significantly enhance ecosystem resilience in the Northern Hemisphere

Ecological Indicators
Greening is asynchronous with ecosystem resilience in the context of vegetation restoration, thus highlighting the uncertainty in predicting the future sustainability of ecosystems.
Jingjing Zhang, Xingming Hao, Yongchang Liu, Xuewei Li, Qixiang Liang, Fan Sun, Mengtao Ci, Yupeng Li   +7 more
doaj   +1 more source

Critical slowing-down in classical and quantum Heisenberg magnetic molecules

, 2004
Schröder C, Schnack J, Mentrup D, Luban M. Critical slowing-down in classical and quantum Heisenberg magnetic molecules. Journal of Magnetism and Magnetic Materials.
Schröder, Christian, Luban, M, Mentrup, D, Schnack, J, Mentrup, Detlef, Schröder, Christian ; https://orcid.org/, Luban, Marshall, Schnack, Jürgen ; https://orcid.org/   +7 more
core   +1 more source

DataSheet1_Fractional critical slowing down in some biological models.pdf

, 2023
The critical slowing down (CSD) phenomenon of the switching time in response to perturbation β (0 D can be reduced or increased, compared with the ordinary derivative case (α = 1).
R. A. Alharbey (12289744), S. S. Hassan (14727919)   +1 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Failure precursor characteristics of different types of rocks under load: insights from critical slowing down of acoustic emission

Geomechanics and Geophysics for Geo-Energy and Geo-Resources, 2023
In this study, uniaxial compression tests and simultaneous acoustic emission (AE) monitoring were carried out on four rocks (yellow sandstone, white sandstone, marble and limestone).
Jianchun Ou, Enyuan Wang, Xinyu Wang
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source