Results 41 to 50 of about 559,608 (264)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Design of the blisk of an aircraft turbojet engine and verification of its resonance free operation

Applied and Computational Mechanics, 2016
Integral turbine wheels belong to one of the most stressed parts of jet aircraft engines. In addition to high rotational speeds and temperatures, they are also subjected to dynamic forces from a non-uniform pressure field in the flow path. Dynamic forces
Chromek L.
doaj  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Possibility of increasing the critical speed of high-speed electric trains using transverse cushioning of tractive motors

Вестник Научно-исследовательского института железнодорожного транспорта, 2023
Introduction. Most modern bullet and high-speed electric trains are equipped with a Class II power actuator with stiff or elastic support of electric motors on the bogie frame.
A. V. Kharitonov
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Quasi-static stability of a ribbed shell interacting with moving load [PDF]

INCAS Bulletin, 2019
Loss of stability of thin-walled structural elements of aircraft is the most common type of destruction. In this work, the definition of the critical velocity of a pressure wave moving over the surface of an acclivous, ribbed cylindrical shell, which is ...
Boris A. ANTUFEV, Olga V. EGOROVA, Lev N. RABINSKIY   +2 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Simulation Analysis and Optimization of the Shearing Type of Quadrangular Rotor

Journal of Harbin University of Science and Technology, 2019
In order to improve the reliability and stability of the mixer rotor, to meet the design requirements of the sheartype foursided rotor, in work this paper, the static analysis and modal analysis of the shearing type of quadrangular rotor were carried out
SUN Quan-ying, CAO Fei-fe, MA Ming-ming, WANG Tian-peng, ZHOU Zong-ping   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source