Results 61 to 70 of about 559,608 (264)

A study on the contact condition and the collision behaviour of a wheelset with a flat set on a roller rig

Nihon Kikai Gakkai ronbunshu, 2018
To investigate and understand conditions of mutual contact and collision impact between a wheel-flat and a roller rig, we first did a bench test of a bogie with the wheel flat on the roller rig.
Yasutaka MAKI, Yoshiaki TERUMICHI
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Towards Accurate Prediction of Unbalance Response, Oil Whirl and Oil Whip of Flexible Rotors Supported by Hydrodynamic Bearings

Lubricants, 2016
Journal bearings are used to support rotors in a wide range of applications. In order to ensure reliable operation, accurate analyses of these rotor-bearing systems are crucial.
Rob Eling, Mathys te Wierik, Ron van Ostayen, Daniel Rixen   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Physiological Correspondence Between Different Indexes of High-Intensity Endurance Exercise in Young Male Runners

Sports
Critical speed (CS), the respiratory compensation point (RCP), and the midpoint between gas exchange threshold and maxial oxygen uptake (VO2max) (i.e., 50%Δ) have been considered indexes able to demarcate the boundary between the heavy and severe ...
Danilo A. Massini, Renato A. C. Caritá, Tiago A. F. Almeida, Anderson G. Macedo, Víctor Hernández-Beltrán, José M. Gamonales, Mário C. Espada, Dalton M. Pessôa Filho   +7 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

DESIGN-STAGE ADJUSTMENT OF ROTOR CRITICAL SPEEDS

Вестник Донского государственного технического университета, 2018
Know-how and the computer-applied diversity algorithm (removal) for the operational and critical rotation speeds of the rotor at the design stage (critical frequencies adjustment) are offered.
Oleg O. Polushkin, Oleg A. Polushkin
doaj  

The Influence of Axial-Bearing Position of Active Magnetic Suspension Flywheel Energy Storage System on Vibration Characteristics of Flywheel Rotor

Actuators
This study introduces a flywheel rotor support structure for an active magnetic suspension flywheel energy storage system. In this structure, there is an axial offset between the axial-bearing position and the mass-center of the flywheel rotor, which ...
Lei Wang, Tielei Li, Zhengyi Ren
doaj   +1 more source