Results 141 to 150 of about 1,386,732 (266)

The limitations of critical incident stress debriefing [PDF]

Irish Journal of Psychological Medicine, 2001
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Mechanosensitive reactive oxygen Species:A precision medicine target for oxidative stress-related diseases. [PDF]

Mechanobiol Med
Huang K.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Occupational stress, job satisfaction, and intention to leave among critical care nurses during the COVID-19 pandemic: a cross-sectional study in Lebanon. [PDF]

Front Public Health
Bani-Hani M, Al-Ghabeesh S, Rayan A, Tai P, Fawaz M, Salloum Z, Alyami H.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Dissecting bone marrow and plasma exosomal microRNA profiles following trauma. [PDF]

Surgery
Peethala A, Yoham AL, Bible LE, Kannan KB, Wheeler C, Hernández-Ríos M, Rodhouse CE, Maile R, Efron PA, Mohr AM.   +9 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Redox regulation of PDE6 and cGMP signaling in diabetic retinal neurodegeneration. [PDF]

Biochem Biophys Rep
Perez-Martinez CJ, Lewis-Luján LM, Cota-Arrayales CA, Guerrero-Magaña DE, Vargas-Durazo JT, Trushin MV, Osadchuk MA, Iloki-Lewis AP, Galvez-Ruiz JC, Iloki-Assanga SB.   +9 more
europepmc   +1 more source