Results 121 to 130 of about 1,504,011 (315)

Galectin-3/CD146 interaction promotes renal damage and systemic inflammation after acute kidney injury

Scientific Reports
Galectin-3 (Gal-3) expression is abnormally increased after renal ischemic injury, in various studies, further promoting tissue damage. Gal-3 may interact with the endothelial layer to induce inflammation during renal injury, linking the systemic and ...
L. Boutin, S. M. Figueroa, E. Roger, S. Hadjadj, R. Piedagnel, E. Gayat, J.-L. Samuel, M. Legrand, F. Dépret, Christos E. Chadjichristos   +9 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - Copyright @ 2012
Vivek Muthurangu, Jones, Alexander, Muthurangu Vivek, Deanfield, John E., McMillan Merlin R., Andrew M Taylor, Muthurangu, Vivek, Jones, RW, Jens C Pruessner, Steeden Jennifer A., Deanfield John E., Grzegorz T Kowalik, Taylor Andrew M., Taylor, Andrew M., Alexander Jones, Jones Alexander, Steeden, JA, Russell W Jones, Jones, Russell W., Merlin R McMillan, Muthurangu, V, Kowalik, GT, John E Deanfield, Pruessner, Jens C., Pruessner, JC, McMillan, MR, Deanfield, JE, Kowalik, Grzegorz T., Jones Russell W., Kowalik Grzegorz T., McMillan, Merlin R., Jones, A, Pruessner Jens C., Taylor, AM, Steeden, Jennifer A., Jennifer A Steeden   +35 more
core   +1 more source

Neuropeptide therapeutics to repress lateral septum neurons that disable sociability in an autism mouse model

Cell Reports Medicine
Summary: Confronting oxytocin and vasopressin deficits in autism spectrum disorders and rare syndromes brought promises and disappointments for the treatment of social disabilities.
Amélie M. Borie, Yann Dromard, Prabahan Chakraborty, Pierre Fontanaud, Emilie M. Andre, Amaury François, Pascal Colson, Françoise Muscatelli, Gilles Guillon, Michel G. Desarménien, Freddy Jeanneteau   +10 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Predictors of mortality in patients with stress-induced cardiomyopathy developed during critical care

, 2013
PURPOSE: The aims of this study were to define predictors of in-hospital mortality and to explore the implication of Acute Physiology and Chronic Health Evaluation (APACHE) II score in patients with stress-induced cardiomyopathy (SCM) developed during ...
나성원, 장혁재, 최용선
core   +1 more source

Burnout trajectories among healthcare workers during a pandemic, and predictors of change

BMC Health Services Research
Background While several cross-sectional studies have suggested high burnout levels among health-care workers (HCW) during the Covid-19 pandemic, fewer studies have examined longitudinal trajectories of burnout.
Kristina Bondjers, Philip Hyland, Dan Atar, Jan Olav Christensen, Kristian Bernhard Nilsen, Solveig Klaebo Reitan, Leiv Arne Rosseland, Tore Wentzel-Larsen, Hilde Wøien, John Anker Zwart, Grete Dyb, Synne Stensland   +11 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Electric foot-shock stress drives TNF-alpha production in the liver of IL-6-deficient mice

, 2004
Objectives: Accumulating evidence has shown that interleukin-6 (IL-6) has pleiotropic effects on a variety of biological functions, including its antiapoptotic potential during liver injury.
Chida, Y, Motomura, Y, Kubo, C, Sudo, N
core  

Estrés y ansiedad en el entorno de cuidados intensivos

ENE. Revista de Enfermería
El ambiente de trabajo con sus características intrínsecas es fuente de estrés intenso. El ambiente de cuidados intensivos es un campo muy específico generador e trastornos psíquicos y fisiológicos asociados al estrés.
Emilia Romero de San Pío, Santiago González Sánchez, María Jesús Romero San Pío   +2 more
doaj   +1 more source