Results 111 to 120 of about 1,504,011 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Job-related stress and burnout

, 2002
Occupational stress is a topic of substantial interest to organizational researchers and managers, as well as society at large. Stress arising from work conditions can be pervasive and significant in its impact on individuals, their families and ...
Cooper, Cary L., O’Driscoll, Michael P.   +1 more
core  

Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury

, 2016
Context: Military recruits and elite athletes are susceptible to stress fracture injuries. Genetic predisposition has been postulated to have a role in their development.
Gallagher, JA, Moran, Daniel, Varley, Ian, Sale, C, Ranson, Craig, Moran, DS, Gartland, Alison, Greeves, JP, Ranson, C, Friedman, E, Fraser, WD, Gallagher, James A, Wilson, Peter J, Varley, I, Sale, Craig, Fraser, William, Gartland, A, Stellingwerff, Trent, Friedman, Eitan, Stellingwerff, T, Yanovich, R, Hughes, David C, Greeves, Julie, Yanovich, Ran, Wilson, PJ, Hughes, DC   +25 more
core   +1 more source

Do you want me to be perfect? Two longitudinal studies on socially prescribed perfectionism, stress and burnout in the workplace [PDF]

, 2012
Stress and burnout in the workplace have a negative impact on organizations and customers and are estimated to cost the economy billions every year. To help identify employees at high risk, it is important to know what individual differences contribute ...
Stoeber, Joachim, Childs, Julian H.
core   +1 more source

Moral distress and protective work environment for healthcare workers during public health emergencies

BMC Medical Ethics
Background Public health emergencies, such as the Covid-19 pandemic, put great pressure on healthcare workers (HCW) across the world, possibly increasing the risk of experiencing ethically challenging situations (ECS).
K. Bondjers, Alve K. Glad, H. Wøien, T. Wentzel-Larsen, D. Atar, SK. Reitan, LA. Rosseland, JA. Zwart, G. Dyb, SØ. Stensland   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development and psychometric validation of the frontline health workers’ occupational risk and characteristics in emergencies index (FORCE-index) – The covid Hospital cohort study

Public Health in Practice
Objectives: A lack of tools for the systematic identification of frontline health workers' changing occupational risks, characteristics, and needs, poses a major barrier to supporting vital personnel to stay in practice through health emergencies and ...
Synne Øien Stensland, Kristina Bondjers, John-Anker Zwart, Leiv Arne Rosseland, Dan Atar, Jan Olav Christensen, Dagfinn Matre, Kristin Alve Glad, Tore Wentzel-Larsen, Hilde Wøien, Grete Dyb   +10 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

2010 Annual Evidence Update on Critical Illness Rehabilitation

, 2010
For this annual evidence update a detailed literature review was undertaken to retrieve any evidence published subsequent to the literature search which formed the basis for the NICE guideline.
Parker, Robert, Griffiths, John, Morris, Craig, Kishen, Roop, Gibson, Vanessa, Treacher, David   +5 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source