Results 61 to 70 of about 11,241,667 (250)

Technologies, Deafness, and Critical Compromise

open access: yes, 2005
C1 - Refereed Journal ArticleThe original aim in this research was to explore the responses of people who identify as Deaf, deaf, or hearing impaired to genetic testing for deafness. Nineteen in-depth interviews were undertaken with Deaf and deaf/hearing
Gillam, L   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Defense Technologies: DOD's Critical Technologies Lists Rarely Inform Export Control and Other Policy Decisions [PDF]

open access: yes, 2006
A letter report issued by the Government Accountability Office with an abstract that begins "Major acquisitions in the Department of Defense's (DOD) force transformation rely on maintaining technological superiority to ensure U.S.
United States. Government Accountability Office.
core  

Geospatial Technologies in Archaeology

open access: yes, 2023
This chapter describes the application of geospatial technologies in archaeology and explains how they present new ways of understanding and visualizing the past. It examines the value of using key technologies of GIS and remote sensing (including Lidar),
Specht, D., Kent, A.J.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Future CCS Technologies : European Zero Emission Technology and Innovation Platform [PDF]

open access: yes, 2017
ZEP has published a report entitled "Future CCS Technologies". The report has been developed following COP21 and the aim of limiting the global temperature increase to well below 2°C.
Network Technology – Future CCS Technologies Temporary Working Group
core   +2 more sources

Polynomial modelling of high-quality yet incomplete rare earth element data sets and a holistic assessment of REE anomalies

open access: yesScientific Reports
Rare earth elements (REEs) are powerful proxies used in many (bio-)geochemical studies. Interpretation of REE data relies on normalised REE patterns and anomaly quantification, and requires complete data.
David M. Ernst   +3 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

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