Results 71 to 80 of about 11,241,667 (250)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Mechanisms and Critical Technologies of Transport Inhibitor Agent (TIA) throughout C-S-H Nano-Channels. [PDF]

Materials (Basel), 2022
Luo Q, Huang J.
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Critical Electrochemistry Technologies Applicable in Space Exploration

Advanced Science
Electrochemistry is versatile, less subject to external influences, and has great potential for the exploration of the unpredictable space environment.
Ruisi Xu, Zepeng Lv, Shaolong Li, Jilin He, Jianxun Song   +4 more
doaj   +1 more source

Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

Critical Care, 2017
Background Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic tool for H1N1 pneumonia.
Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Anand Kumar, Sachin Yende, Derek C. Angus, Brent W. Winston, the Canadian Critical Care Translational Biology Group (CCCTBG)   +7 more
doaj   +1 more source

Digital technologies in the curriculum: national and international

, 2015
To fully engage with the teaching of the digital technologies curriculum, it is helpful to undertake a critical examination of Australian national and state computing curricula within a global context.
Zagami, Jason
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Agreement Technologies for Supporting the Planning and Execution of Transports

, 2012
The use of agreement technologies in the planning and execution of goods transports is analyzed. We have previously suggested an approach called Plug and Play Transport Chain Management (PnP TCM) that provides agent-based support for key tasks, such as ...
Marie Gustafsson Friberger, Andreas Jacobsson, Jacobsson, Andreas,, Persson, Jan A.,, Johan Holmgren, Davidsson, Paul,, Holmgren, Johan,, Paul Davidsson, Jan A. Persson, Gustafsson Friberger, Marie   +9 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source