Results 81 to 90 of about 11,241,667 (250)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Disruptive Technologies, A Critical Yet Hopeful View
Cadmus, 2017 A new perspective is attempted on the role played by Information and Communication Technologies (ICTs) in the evolution of human societies in the last few decades.
Carlos Alvarez Pereira
doaj
Critical success factors to yield business benefits from semantic technologies
, 2011 The purpose of this chapter is to explore opportunities offered by and issues associated with the use of emergent semantic technologies in enhancing an enterprisee's business position.
Rowland-Campbell, Anni +2 more
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Carnitine dysregulation in diabetic kidney disease: from pathogenic mechanism to precision biomarker
Journal of Translational MedicineCarnitine is essential for mitochondrial fatty acid β-oxidation and redox homeostasis, and mounting evidence shows that carnitine metabolism is profoundly perturbed in diabetic kidney disease (DKD).
Yuanhua Dai +10 more
doaj +1 more source
National Adult Critical Care Capacity Census and Activity Census 2016
, 2017 he annual national adult Critical Care Bed Capacity Census measures capacity as at 30th September 2016. The Census reports a capacity of 237 adult critical care (Level3 ICU and Level2 HDU) beds.
HSE Acute Hospitals Division Critical Care Programme
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Critical Materials for Low-Carbon Technologies in US Markets [PDF]
, 2023 The deployment of any new technology at large scale burdens the supply of the materials from which it is made, and the availability (or lack thereof) of those materials can, in turn, impact the deployment of the technology. Here, I describe the impact of
King, Alexander
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source