Results 91 to 100 of about 6,755,416 (402)

An audit of airway management in critically ill patients in a sub-Saharan tertiary hospital

Journal of Clinical Sciences, 2016
Critically ill patients have poor physiological reserves, and are at increased risk of cardiopulmonary complications such as hypoxia, hypotension, arrhythmias and cardiac arrest when undergoing airway management.
Oyebola Olubodun Adekola, Olusola Temitayo Kushimo, Esohe Ivie Ohuoba, Gabriel Kolawole Asiyanbi, Olugbenga Oluseyi Olusoji, Muyiwa Kayode Rotimi   +5 more
doaj   +1 more source

Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]

, 2012
Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Di Gangi, Stefania, Kruger, Peter S., McAuley, Danny F., Perkins, Gavin D., Scales, Damon C., Shankar-Hari, Manu, Terblanche, Marius   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The significance of RDW and LDH in pediatric critical illness

Egyptian Pediatric Association Gazette
Background The LDH level, which can be easily assessed, was described to be independently associated with in-hospital mortality. Also, independent of illness severity in critically ill children, red cells distribution width (RDW)was associated with ...
Radwa Iraqy, Hala Fouad, Rana Mohamed, Hebat Allah Algebaly, Elshimaa Ahmed   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRANSFUSION TRIGGERS IN CRITICALLY ILL PATIENTS

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine the frequency of inappropriate transfusions in tertiary care hospital. Study Design: Cross sectional study. Place and Duration of Study: General Intensive Care Unit (ICU) Lady Reading Hospital Peshawar, from Dec 2017 to Feb ...
Aisha Kulsoom Mufti
doaj  

Disturbances of sodium in critically ill adult neurologic patients: A clinical review [PDF]

, 2006
Disorders of sodium and water balance are common in critically ill adult neurologic patients. Normal aspects of sodium and water regulation are reviewed. The etiology of possible causes of sodium disturbance is discussed in both the general inpatient and
Crocker, M, Smith, M, Tisdall, M, Watkiss, J   +3 more
core  

Health status of critically ill trauma patients [PDF]

, 2014
Aims and objectives: To describe the recovery of trauma intensive care patients up to six months posthospital discharge. Background: Injury is a leading cause of preventable mortality and morbidity worldwide, with approximately 10% of hospitalised ...
Aitken, Aitken, Australian Bureau of Statistics, Australian Institute of Health and Welfare (AIHW), Badia, Broadbent, Connelly, Covic, Cuthbertson, Dallow, DiMartini, Friedman, Harris, Hawthorne, Holtslag, Hyder, Jackson, Jackson, Kessler, Korosec Jagodic, Lee, Livingston, Lorig, Lorig, Mata, Mathers, Needham, Niskanen, O'Donnell, Peden, Richmond, Richmond, Ringdal, Rutter, Shnek, Sluys, Toien, Ware, Wong, Zimet, Zimet   +40 more
core   +2 more sources

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions.

Journal of the American Medical Association (JAMA), 2020
This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 ...
M. Kox, N. Waalders, E. Kooistra, Jelle Gerretsen, P. Pickkers   +4 more
semanticscholar   +1 more source