Results 131 to 140 of about 6,755,416 (402)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dependency in Critically Ill Patients

Global Qualitative Nursing Research, 2016
By necessity, critically ill patients admitted to intensive care units (ICUs) have a high level of dependency, which is linked to a variety of negative feelings, such as powerlessness.
Rumei Yang
doaj   +1 more source

Conservative versus conventional oxygen therapy for critically ill patients: a Meta-analysis of randomized controlled trials [PDF]

, 2020
Hui‐Bin Huang, Xiaoli Chen, Beilei Zhang, Hui Lin   +3 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Transfusion thresholds and beyond [PDF]

, 2016
Comment on Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials.
Biancofiore, G, Franchini, M., Liumbruno, Gm, Marano, G, Mengoli, C, Vaglio, Stefania   +5 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Successful treatment of a resistant invasive disseminated Fusarium infection in an immunocompetent patient

Medical Mycology Case Reports
Fusariosis is a severe fungal infection associated with high mortality rates and an increasing incidence. However, its treatment remains challenging due to the frequent resistance of Fusarium species to conventional antifungal therapies.
Frantzeska Frantzeskaki, Nikolas Stratopoulos, Sandra Elise van der Griend, Ioannis Renieris, Kostantinos Thomas, Iraklis Tsagkaris   +5 more
doaj   +1 more source

Intravenous magnesium therapy in critically ill patients [PDF]

, 1993
Michael F. James
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Lateral positioning for critically ill adult patients

, 2008
We aim to assess the effect of the lateral position compared to other body positions on patient outcomes (mortality, morbidity and clinical adverse events during and following positioning) in critically ill adult patients.
Bucknall, Tracey K., Glanville, David, Hewitt, Nicky   +2 more
core   +1 more source