Results 51 to 60 of about 743,928 (343)

Determining optimal outcome measures in a trial investigating no routine gastric residual volume measurement in critically ill children [PDF]

, 2020
Background Choosing trial outcome measures is important. When outcomes are not clinically relevant or important to parents/patients, trial evidence is less likely to be implemented into practice.
Andrzejewska, Izabela, Arch, Barbara, Beissel, Anne, Deja, Elizabeth, Dorling, Jon, Eccleson, Helen, Gale, Chris, Hickey, Helen, Jones, Ashley P., Latten, Lynne, Pathan, Nazima, Preston, Jenny, Roper, Louise, the Paediatric Intensive Care Society Study Group (PICS-SG), Tume, Lyvonne N., Valla, Frederic V., Woolfall, Kerry   +16 more
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Epidemiology and characteristics of nosocomial infections in critically ill patients in a tertiary care intensive care unit of Northern India

Saudi Journal of Anaesthesia, 2017
Background and Aims: The prevalence of nosocomial infection is higher in the Intensive Care Unit (ICU) than other areas of the hospital. The present observational study was undertaken to describe the epidemiology and characteristics of nosocomial ...
Anirban Hom Choudhuri, Mitali Chakravarty, Rajeev Uppal   +2 more
doaj   +1 more source

A fresh look at paralytics in the critically ill: real promise and real concern. [PDF]

, 2012
Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails.
Kenyon, Nicholas J, Price, David, Stollenwerk, Nicholas   +2 more
core   +2 more sources

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

- Is central venous catheter placement overrated for inotropic support: a voice from low-resource setting

Journal of the Pakistan Medical Association
Dear Editor, I am reaching out to shed light on the prevalent issue regarding the perceived necessity of placing central venous catheters in the emergency department for delivering inotropic agents to critically ill patient Although Central venous ...
Zofishan Anwar, Madiha Ismail
doaj   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Antioxidants in Critical Illness [PDF]

Archives of Surgery, 2001
Oxidative stress has been implicated in the manifestations of critical illnesses, including ischemia and reperfusion injury and systemic inflammatory states. This review describes the evidence for increased oxidative stress in critically ill patients and explores the data regarding antioxidant therapy for these conditions.
Eileen M. Bulger, Ronald V. Maier
openaire   +2 more sources

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Health status of critically ill trauma patients [PDF]

, 2014
Aims and objectives: To describe the recovery of trauma intensive care patients up to six months posthospital discharge. Background: Injury is a leading cause of preventable mortality and morbidity worldwide, with approximately 10% of hospitalised ...
Aitken, Aitken, Australian Bureau of Statistics, Australian Institute of Health and Welfare (AIHW), Badia, Broadbent, Connelly, Covic, Cuthbertson, Dallow, DiMartini, Friedman, Harris, Hawthorne, Holtslag, Hyder, Jackson, Jackson, Kessler, Korosec Jagodic, Lee, Livingston, Lorig, Lorig, Mata, Mathers, Needham, Niskanen, O'Donnell, Peden, Richmond, Richmond, Ringdal, Rutter, Shnek, Sluys, Toien, Ware, Wong, Zimet, Zimet   +40 more
core   +2 more sources