Results 121 to 130 of about 1,231,981 (407)

Association of frailty and sarcopenia with short-term mortality in older critically ill patients

The Journal of Nutrition, Health and Aging
Background: There is still no study on the use of the SARC-CalF questionnaire for older critically ill patients. Moreover, there is limited evidence on whether a combination of sarcopenia and frailty can provide incremental improvements in risk ...
Weimin Bai, Hongbo Ge, Han Han, Juan Xu, Lijie Qin   +4 more
doaj   +1 more source

Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019

Clinical Infectious Diseases, 2020
Although the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in respiratory specimens has been widely used to diagnose coronavirus disease 2019 (COVID-19), it is undeniable that serum SARS-CoV-2 nucleic acid ...
Xiaohua Chen, Binghong Zhao, Y. Qu, Yurou Chen, J. Xiong, Yong Feng, Dong Men, Qianchuan Huang, Yanjun Liu, Bo Yang, Jinya Ding, Feng Li   +11 more
semanticscholar   +1 more source

Continuous Infusion of Piperacillin/Tazobactam in Septic Critically Ill Patients - a Multicenter Propensity Matched Analysis [PDF]

, 2012
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients with microbiologically documented infections is currently unknown.
Bento, L, Estilita, J, Gonçalves-Pereira, J, Gouveia, J, Janeiro, S, Monteiro, C, Paulino, C, Póvoa, P, Salgueiro, A, Serra Oliveira, B, Vieira, A   +10 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Application progress of BLUE and modified protocols in diagnosing and monitoring pulmonary lesions in EICU patients [PDF]

Zhenduanxue lilun yu shijian
Lung ultrasound (LUS) has important application value in the diagnosis and treatment of patients in intensive care units because of its advantages of non-radiation, low cost, real-time imaging, bedside operability, and no risk of patient transport.
XU Pengyu, CHI Cheng, ZHANG Xiaoxia
doaj   +1 more source

Experience with daptomycin daily dosing in ICU patients undergoing continuous renal replacement therapy [PDF]

, 2018
Purpose: For critically ill patients undergoing continuous renal replacement therapy (CRRT), daptomycin dosing recommendations are scarce. We, therefore, retrospectively assessed routinely measured daptomycin plasma concentrations, daptomycin dose ...
Corti, N., Fehr, J., Preiswerk, B., Rudiger, A.   +3 more
core  

How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it? [PDF]

, 2014
The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients exhibit marked variability. This variability results from pathophysiological changes that occur in critically ill patients.
Felton, T. W., Hope, W. W., Roberts, J. A.   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Triage and Ongoing Care for Critically Ill Patients in the Emergency Department: Results from a National Survey of Emergency Physicians [PDF]

, 2020
Introduction: We conducted a cross-sectional study at the Icahn School of Medicine at Mount Sinai to elicit emergency physician (EP) perceptions regarding intensive care unit (ICU) triage decisions and ongoing management for boarding of ICU patients in ...
Mathews, Kusum S., Nelson, Judith E., Richardson, Lynne D., Rodriguez, Sandra M.   +3 more
core